ArticleAge (Dordrecht, Netherlands)2014
Accelerated aging of reproductive capacity in male rat offspring of protein-restricted mothers is associated with increased testicular and sperm oxidative stress.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Subnutrition during gestation and lactation affects testicular development, serum testosterone concentration and androgen receptor expression in myoid cells of mature rats.Animal reproduction · 2026Article
- Early and long-term effects of maternal protein restriction on offspring organs and systems: insights from the developmental origins of health and disease (DOHaD).Biogerontology · 2025Review
- Maternal protein restriction affects the differentiation of cells in the epididymal epithelium lining of 44-day-old rats.Biology open · 2025Article
- Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration.Frontiers in veterinary science · 2024Article
- Article
- Maternal Protein Restriction Alters the Expression of Proteins Related to the Structure and Functioning of the Rat Offspring Epididymis in an Age-Dependent Manner.Frontiers in cell and developmental biology · 2022Article
- Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Review
- Article
- Maternal protein restriction differentially alters the expression of AQP1, AQP9 and VEGFr-2 in the epididymis of rat offspring.International journal of molecular sciences · 2019Article
- Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing.The Journal of physiology · 2017Article
- A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise.Frontiers in physiology · 2017Article
- Epigenetic inheritance of proteostasis and ageing.Essays in biochemistry · 2016Review
- Intrauterine growth restriction programs an accelerated age-related increase in cardiovascular risk in male offspring.American journal of physiology. Renal physiology · 2016Article
- Transgenerational effects of maternal diet on metabolic and reproductive ageing.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility.International journal of obesity (2005) · 2015Article
- The janus face of stress on reproduction: from health to disease.International journal of endocrinology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal protein restriction (MPR) in pregnancy causes life course organ dysfunction, but few studies link the developmental origins of disease hypothesis to early aging. Suboptimal developmental nutrition increases oxidative stress (OS) and male infertility, damaging sperm function. We hypothesized that MPR in pregnancy accelerates age-related changes in testicular and sperm function related to both maternal diet and increased testicular OS in rat offspring. We studied male rats whose pregnant mothers ate either control (C, 20 % casein) or restricted (R, 10 % casein) isocaloric diet. After birth, mothers and offspring ate C diet. Testes were retrieved at 19 days gestation and across the life course (postnatal day (PND) 21, 36, 110, and 850) to measure OS markers, antioxidant enzymes, serum FSH, LH, and testosterone, and PND 110 sperm OS and quality. Fertility rate was evaluated at PND 110, 450, and 850. Offspring showed age- and MPR-related changes in testosterone, testicular OS markers and antioxidant enzymes and fertility, and maternal diet-related OS and sperm antioxidant enzyme changes. Developmental programming is considered a key factor in predisposing to chronic disease. Our data show that programming also plays an important role in aging trajectory. This interaction is a little studied area in aging biology that merits more investigation.
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