ArticleEuropean radiology2015
γ-H2AX foci as in vivo effect biomarker in children emphasize the importance to minimize x-ray doses in paediatric CT imaging.
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Quantifying Radiation Effects of Iodinated Contrast Media in Pediatric CT Using DNA Damage Biomarkers.International journal of molecular sciences · 2026Article
- Review
- Biomarkers of mitochondrial stress and DNA damage during pediatric catheter-directed neuroangiography - a prospective single-center study.Pediatric radiology · 2024Article
- The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo.Radiation and environmental biophysics · 2023Article
- Optimal timing of a γH2AX analysis to predict cellular lethal damage in cultured tumor cell lines after exposure to diagnostic and therapeutic radiation doses.Journal of radiation research · 2023Article
- Artificial Intelligence for Radiation Dose Optimization in Pediatric Radiology: A Systematic Review.Children (Basel, Switzerland) · 2022Review
- Simultaneous effect of gamma and Wi-Fi radiation on gamma-H2Ax expression in peripheral blood of rat: A radio-protection note.Biochemistry and biophysics reports · 2022Article
- A deep learning model (FociRad) for automated detection of γ-H2AX foci and radiation dose estimation.Scientific reports · 2022Article
- EANM position paper on the role of radiobiology in nuclear medicine.European journal of nuclear medicine and molecular imaging · 2021Article
- Radiobiological risks following dentomaxillofacial imaging: should we be concerned?Dento maxillo facial radiology · 2021Review
- α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [European journal of nuclear medicine and molecular imaging · 2021Article
- Prediction of the Acute or Late Radiation Toxicity Effects in Radiotherapy Patients Using Ex Vivo Induced Biodosimetric Markers: A Review.Journal of personalized medicine · 2020Review
- DNA double-strand breaks of human peripheral blood lymphocyte induced by CT examination of oral and maxillofacial region.Clinical oral investigations · 2020Article
- DNA Damage in Blood Leukocytes of Prostate Cancer Patients Undergoing PET/CT Examinations with [Cancers · 2020Article
- Evaluation of machine learning models for automatic detection of DNA double strand breaks after irradiation using a γH2AX foci assay.PloS one · 2020Article
- RISK EVALUATION IN THE LOW-DOSE RANGE CT FOR RADIATION-EXPOSED CHILDREN, BASED ON DNA DAMAGE.Radiation protection dosimetry · 2019Review
- Changes in the Selected Antioxidant Defense Parameters in the Blood of Patients after High Resolution Computed Tomography.International journal of environmental research and public health · 2019Article
- Evaluating Gamma-H2AX Expression as a Biomarker of DNA Damage after X-ray in Angiography Patients.Journal of biomedical physics & engineering · 2018Article
- DNA double-strand breaks in blood lymphocytes induced by two-dayEuropean radiology · 2018Article
- Efficient inhibition of cervical cancer by dual drugs loaded in biodegradable thermosensitive hydrogel composites.Oncotarget · 2018Article
Corrections and comments
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Authors and funding
10 authors.
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Abstract
objectivesInvestigation of DNA damage induced by CT x-rays in paediatric patients versus patient dose in a multicentre setting.
methodsFrom 51 paediatric patients (median age, 3.8 years) who underwent an abdomen or chest CT examination in one of the five participating radiology departments, blood samples were taken before and shortly after the examination. DNA damage was estimated by scoring γ-H2AX foci in peripheral blood T lymphocytes. Patient-specific organ and tissue doses were calculated with a validated Monte Carlo program. Individual lifetime attributable risks (LAR) for cancer incidence and mortality were estimated according to the BEIR VII risk models.
resultsDespite the low CT doses, a median increase of 0.13 γ-H2AX foci/cell was observed. Plotting the induced γ-H2AX foci versus blood dose indicated a low-dose hypersensitivity, supported also by an in vitro dose-response study. Differences in dose levels between radiology centres were reflected in differences in DNA damage. LAR of cancer mortality for the paediatric chest CT and abdomen CT cohort was 0.08 and 0.13 ‰ respectively.
conclusionCT x-rays induce DNA damage in paediatric patients even at low doses and the level of DNA damage is reduced by application of more effective CT dose reduction techniques and paediatric protocols. .
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