ReviewNature reviews. Neuroscience2014
The molecular bases of the suicidal brain.
Review in Nature reviews. Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 7 syntheses or guidelines pooled it, 274 citations in OpenAlex.
- Gene expression meta-analysis in the prefrontal cortex: unraveling biological underpinnings of suicidal risk.BMC psychiatry · 2026Pooled it
- Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts.Translational psychiatry · 2026Pooled it
- Cluster headache suicidality: a systematic review with a meta-analysis.The journal of headache and pain · 2025Pooled it
- Individual-level risk factors for suicide mortality in the general population: an umbrella review.The Lancet. Public health · 2023Pooled it
- Brain Differences Associated with Self-Injurious Thoughts and Behaviors: A Meta-Analysis of Neuroimaging Studies.Scientific reports · 2020Pooled it
- Suicidal ideation and subsequent completed suicide in both psychiatric and non-psychiatric populations: a meta-analysis.Epidemiology and psychiatric sciences · 2018Pooled it
- Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development.EBioMedicine · 2017Pooled it
- Pharmacogenes Associated with Suicidal Behavior: Addressing a Potential Therapeutic Window.Actas espanolas de psiquiatria · 2026Review
- Suicide risk among individuals admitted to an acute psychiatric ward: clinical characteristics, attachment pattern and dignity perception.Frontiers in psychiatry · 2026Article
- Suicide Behavior as a Distinct Psychobiology in Major Depression.Advances in experimental medicine and biology · 2026Review
- Epigenetic and Transcriptomic Alterations of Protein Aggregation-Linked Genes in Suicide: A Pilot Study.Genes · 2025Article
- Epigenetics and immunology: Under-recognized aspects of suicidality.World journal of psychiatry · 2025Review
- From trauma to depression: structural, synaptic, epigenetic, and molecular pathways linking early stress to lifelong vulnerability.Frontiers in psychiatry · 2025Review
- Associations of altered leukocyte DDR1 promoter methylation and childhood trauma with bipolar disorder and suicidal behavior in euthymic patients.Molecular psychiatry · 2024Article
- SNORA69 is up-regulated in the lateral habenula of individuals with major depressive disorder.Scientific reports · 2024Article
- A Prospective Multicenter Longitudinal Analysis of Suicidal Ideation among Long-COVID-19 Patients.Healthcare (Basel, Switzerland) · 2024Article
- Embers of the Past: Early Childhood Traumas Interact with Variation inInternational journal of molecular sciences · 2024Article
- The Role of Emotion Dysregulation in Understanding Suicide Risk: A Systematic Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates.Frontiers in immunology · 2024Review
- Proteome analysis of the prefrontal cortex and the application of machine learning models for the identification of potential biomarkers related to suicide.Frontiers in psychiatry · 2024Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Suicide ranks among the leading causes of death around the world and takes a heavy emotional and public health toll on most societies. Both distal and proximal factors contribute to suicidal behaviour. Distal factors - such as familial and genetic predisposition, as well as early-life adversity - increase the lifetime risk of suicide. They alter responses to stress and other processes through epigenetic modification of genes and associated changes in gene expression, and through the regulation of emotional and behavioural traits. Proximal factors are associated with the precipitation of a suicidal event and include alterations in key neurotransmitter systems, inflammatory changes and glial dysfunction in the brain. This Review explores the key molecular changes that are associated with suicidality and discusses some promising avenues for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.