Evidence map›Paper›PMID 25354257›Full record

ArticleMuscle & nerve2015

Guiding intramuscular diaphragm injections using real-time ultrasound and electromyography.

Aarti Sarwal, Michael S Cartwright, Erin Mitchell, Koudy Williams, Francis O Walker, Martin K Childers

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03139695 (High Resolution Ultrasound of Intercostal Muscle and Diaphragm as a Biomarker of Respiratory Muscle Function in Patients on Mechanical Ventilation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03139695 completednot on this map

High Resolution Ultrasound of Intercostal Muscle and Diaphragm as a Biomarker of Respiratory Muscle Function in Patients on Mechanical Ventilation

TypeobservationalSponsorWake Forest University Health SciencesRan2012 to 2016Enrolled75ConditionsInjury of Diaphragm, Mechanical Ventilation Complication, Critical IllnessArmsUltrasound
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Resident Accuracy of Electromyography Needle Electrode Placement Using Ultrasound Verification.PM & R : the journal of injury, function, and rehabilitation · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Aarti SarwalSection on Critical Care Medicine, Department of Anesthesiology Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, 27157-1009, USA; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Michael S Cartwright
Erin Mitchell
Koudy Williams
Francis O Walker
Martin K Childers
Wake Forest University · USUniversity of Washington · US

Funding

Gene therapy in canine myotubular myopathy for clinical translationR01HL115001 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHILDERS, MARTIN K · 2013 to 2017
$3.9M
Diagnostic Ultrasound for Focal NeuropathiesK23NS062892 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CARTWRIGHT, MICHAEL STEPHEN · 2009 to 2013
$703k
Establishing endpoints in canine myotubular myopathy for clinical translationR21AR064503 · NIAMS · UNIVERSITY OF WASHINGTON · PI CHILDERS, MARTIN K · 2012 to 2013
$389k
NHLBI NIH HHS R01 HL115001NHLBI NIH HHS R01HL115001NIAMS NIH HHS R21 AR064503NIAMS NIH HHS R21AR064503NINDS NIH HHS 1K23NS062892NINDS NIH HHS K23 NS062892
6 · The paper itself

Abstract

introductionWe describe a unique method that combines ultrasound and electromyography to guide intramuscular diaphragm injections in anesthetized large animals.

methodsUltrasound was used to visualize the diaphragm on each side of spontaneously breathing, anesthetized beagle dogs and cynomolgus macaques. An electromyography (EMG) needle was introduced and directed by ultrasound to confirm that the needle entered the muscular portion of the diaphragm, and methylene blue was injected. Injection accuracy was confirmed upon necropsy by tracking the spread of methylene blue.

resultsAll methylene blue injections were confirmed to have been placed appropriately into the diaphragm.

conclusionsThis study demonstrates the feasibility and accuracy of using ultrasound and EMG to guide injections and to reduce complications associated with conventional blind techniques. Ultrasound guidance can be used for clinical EMG of the diaphragm. Future applications may include targeted diaphragm injections with gene replacement therapy in neuromuscular diseases.

Indexed as

ElectromyographyUltrasonographyAnimalsDiaphragmDogsInjections, IntramuscularMacaca fascicularisdiaphragmelectromyographyintramuscular injectionreal-timeultrasound

Identifiers

PMID25354257
PMCPMC4293336
OpenAlexW1910401069

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.