Evidence map›Paper›PMID 25354219›Full record

ArticleExpert review of clinical pharmacology2015

How can we improve oral contraceptive success in obese women?

Ganesh Cherala, Alison Edelman

Abstract readEditorial
In one paragraph

Article in Expert review of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ganesh CheralaOregon State University/Oregon Health and Science University - Pharm Practice 2730 SW Moody Ave, Portland, OR, 97201, USA.
Alison Edelman

Funding

Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
Inflammatory cytokine-mediated induction of HIV cardiomyopathyK01RR024120 · NCRR · HARVARD MEDICAL SCHOOL · PI YEARLEY, JENNIFER · 2007 to 2008
$246k
Contraceptive efficacy and body weight: Does obesity affect the risk of failure?R03HD053611 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI EDELMAN, ALISON B · 2006 to 2007
$127k
NCRR NIH HHS 1 UL1 RR024120NCRR NIH HHS K01 RR024120NICHD NIH HHS 2K12HD043488NICHD NIH HHS K12 HD043488NICHD NIH HHS R03 HD053611
6 · The paper itself

Abstract

A rapid increase in obesity rates worldwide further underscores the importance of better understanding the pharmacokinetic alterations in this sub-population and the subsequent effects on pharmacotherapeutics. Pharmacokinetics of contraceptive steroids is altered in obese oral contraceptive users, which may in turn impact efficacy. Our study has identified several dosing strategies that offset these pharmacokinetic changes and may improve effectiveness for obese oral contraception users.

Indexed as

ContraceptionContraceptives, OralFemaleHumansObesityContraceptives, Oraldrug failureobesityoral contraceptionpharmacokineticssteroidal hormones

Identifiers

PMID25354219
PMCPMC4581527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.