ArticleMagnetic resonance in medicine2015
Multivendor implementation and comparison of volumetric whole-brain echo-planar MR spectroscopic imaging.
Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04233788 (Metabolic Characterization of Space Occupying Lesions of the Brain Using in Vivo MR-), which is not on this map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolic Characterization of Space Occupying Lesions of the Brain Using in Vivo MR- (Spectroscopic) Imaging at 3 Tesla and 7 Tesla
Who cites it
43 citing papers in PubMed.
- Applying a Radiation Therapy Volume Analysis Pipeline to Determine the Utility of Spectroscopic MRI-Guided Adaptive Radiation Therapy for Glioblastoma.Tomography (Ann Arbor, Mich.) · 2023Trial
- The Brain Imaging Collaboration Suite (BrICS): A Cloud Platform for Integrating Whole-Brain Spectroscopic MRI into the Radiation Therapy Planning Workflow.Tomography (Ann Arbor, Mich.) · 2019Trial
- Adaptively Optimized Combination of Phased-Array MR Spectroscopy Data Without Noise Correlation Estimation: A Joint Diagonalization Method.NMR in biomedicine · 2026Article
- First-principles multiscale modeling of cerebral hemodynamics enables personalized predictions of human brain temperature.Scientific reports · 2026Article
- Radiation Effects on Normal Brain in Subjects With Recurrent Glioblastoma by Spectroscopic MRI.NMR in biomedicine · 2026Article
- Longitudinal Overlap and Metabolite Analysis in Spectroscopic MRI-Guided Proton Beam Therapy in Pediatric High-Grade Glioma.Tomography (Ann Arbor, Mich.) · 2025Article
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- The Utility of Spectroscopic MRI in Stereotactic Biopsy and Radiotherapy Guidance in Newly Diagnosed Glioblastoma.Tomography (Ann Arbor, Mich.) · 2024Article
- Downfield proton MRSI with whole-brain coverage at 3T.Magnetic resonance in medicine · 2023Article
- Spectroscopic MRI-Based Biomarkers Predict Survival for Newly Diagnosed Glioblastoma in a Clinical Trial.Cancers · 2023Article
- Spectroscopic MRI-Guided Proton Therapy in Non-Enhancing Pediatric High-Grade Glioma.Tomography (Ann Arbor, Mich.) · 2023Article
- Comparisons of healthy human brain temperature predicted from biophysical modeling and measured with whole brain MR thermometry.Scientific reports · 2022Article
- Final Report on Clinical Outcomes and Tumor Recurrence Patterns of a Pilot Study Assessing Efficacy of Belinostat (PXD-101) with Chemoradiation for Newly Diagnosed Glioblastoma.Tomography (Ann Arbor, Mich.) · 2022Article
- Harmonization of multi-scannerFrontiers in neurology · 2022Review
- Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations.NMR in biomedicine · 2021Article
- Accelerated MR spectroscopic imaging-a review of current and emerging techniques.NMR in biomedicine · 2021Review
- The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group.Brain imaging and behavior · 2021Article
- Regional Metabolite Concentrations in Aging Human Brain: Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T.Clinical neuroradiology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeTo assess volumetric proton MR spectroscopic imaging (MRSI) of the human brain on multivendor MRI instruments.
methodsEcho-planar spectroscopic imaging was developed on instruments from three manufacturers, with matched specifications and acquisition protocols that accounted for differences in sampling performance, radiofrequency (RF) power, and data formats. Intersite reproducibility was evaluated for signal-normalized maps of N-acetylaspartate (NAA), creatine (Cre), and choline using phantom and human subject measurements. Comparative analyses included metrics for spectral quality, spatial coverage, and mean values in atlas-registered brain regions.
resultsIntersite differences for phantom measurements were less than 1.7% for individual metabolites and less than 0.2% for ratio measurements. Spatial uniformity ranged from 79% to 91%. The human studies found differences of mean values in the temporal lobe, but good agreement in other white matter regions, with maximum differences relative to their mean of under 3.2%. For NAA/Cre, the maximum difference was 1.8%. In gray matter, a significant difference was observed for frontal lobe NAA. Primary causes of intersite differences were attributed to shim quality, B0 drift, and accuracy of RF excitation. Correlation coefficients for measurements at each site were over 0.60, indicating good reliability.
conclusionA volumetric intensity-normalized MRSI acquisition can be implemented in a comparable manner across multivendor MR instruments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.