Evidence map›Paper›PMID 25353960›Full record

ArticlePloS one2014

Effects of subclinical hypothyroidism on maternal and perinatal outcomes during pregnancy: a single-center cohort study of a Chinese population.

Liang-Miao Chen, Wen-Jun Du, Jie Dai, Qian Zhang, Guang-Xin Si, Hong Yang, En-Ling Ye, Qing-Shou Chen, Le-Chu Yu, Chi Zhang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 11 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 11 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2016
    Pooled it
  12. Trial
  13. Trial
  14. Article
  15. Article
  16. Study of Subclinical Hypothyroidism and its Association with Lipid Profile Among the Rural Population of Chamarajanagara District-A Hospital-Based Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Liang-Miao ChenDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
Wen-Jun DuDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
Jie DaiDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
Qian ZhangDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
Guang-Xin SiDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
Hong YangDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
En-Ling YeDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
Qing-Shou ChenDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
Le-Chu YuDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China.
Chi ZhangChinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China; Ruian Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Xue-Mian LuDepartment of Endocrinology, Third Affiliated Hospital, Wenzhou Medical University, Ruian, Zhejiang, China; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China; Ruian Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Ruian People's Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAdverse maternal outcomes and perinatal complications are closely associated with overt maternal hypothyroidism, but whether these complications occur in women with subclinical hypothyroidism (SCH) during pregnancy remains controversial. The aim of this study was to evaluate the effects of SCH on maternal and perinatal outcomes during pregnancy.

methodsA prospective study of data from 8012 pregnant women (371 women with SCH, 7641 euthyroid women) was performed. Maternal serum samples were collected in different trimesters to examine thyroid hormone concentrations. SCH was defined as a thyroid stimulating hormone concentration exceeding the trimester-specific reference value with a normal free thyroxine concentration. The occurrence of maternal outcomes, including gestational hypertension (GH), gestational diabetes mellitus, placenta previa, placental abruption, prelabor rupture of membranes (PROM), and premature delivery; and perinatal outcomes, including intrauterine growth restriction (IUGR), fetal distress, low birth weight (LBW; live birth weight ≤ 2500 g), stillbirth, and malformation, was recorded. Logistic regression with adjustment for confounding demographic and medical factors was used to determine the risks of adverse outcomes in patients with SCH.

resultsCompared with euthyroid status, SCH was associated with higher rates of GH (1.819% vs. 3.504%, P = 0.020; χ2 = 7.345; odds ratio (OR), 2.243; 95% confidence interval (CI), 1.251-4.024), PROM (4.973% vs. 8.625%, P = 0.002; χ2 = 72.102; adjusted OR, 6.014; 95% CI, 3.975-9.099), IUGR (1.008% vs. 2.965%, <0.001; χ2 = 13.272; adjusted OR, 3.336; 95% CI, 1.745-6.377), and LBW (1.885% vs. 4.582%, P<0.001; χ2 = 13.558; adjusted OR, 2.919; 95% CI, 1.650-5.163).

conclusionsThe results of this study indicate that pregnant women with SCH had increased risks of GH and PROM, and their fetuses and infants had increased risks of IUGR and LBW. Thus, routine maternal thyroid function testing is necessary to improve maternal and perinatal outcomes.

Indexed as

AdultChinaFemaleHumansHypothyroidismPregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesRisk FactorsThyroid HormonesThyroid Hormones

Identifiers

PMID25353960
PMCPMC4212915
OpenAlexW1993466017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.