Evidence map›Paper›PMID 25353349›Full record

ArticlePloS one2014

A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion.

Vijay Sharma, Jothilingam Sivapackiam, Scott E Harpstrite, Julie L Prior, Hannah Gu, Nigam P Rath, David Piwnica-Worms

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Evaluation ofACS omega · 2023
    Article
  4. Article
  5. Review
  6. A brief overview of metal complexes as nuclear imaging agents.Dalton transactions (Cambridge, England : 2003) · 2019
    Review
  7. Article
  8. Emerging Tracers for Nuclear Cardiac PET Imaging.Nuclear medicine and molecular imaging · 2018
    Review
  9. Article
  10. MedChemComm · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Vijay SharmaBRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Jothilingam SivapackiamBRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Scott E HarpstriteBRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Julie L PriorBRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Hannah GuBRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Nigam P RathDepartment of Chemistry and Biochemistry, University of Missouri, St. Louis, Missouri, United States of America.
David Piwnica-WormsBRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Departments of Cell Biology and Physiology and Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Imaging Center · USMallinckrodt (United States) · USUniversity of Missouri–St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo · 2001 to 2026
$128.0M
WU-MDACC Inter-Institutional Molecular Imaging CenterP50CA094056 · NCI · WASHINGTON UNIVERSITY · PI PIWNICA-WORMS, DAVID · 2002 to 2016
$26.3M
NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGINGR01HL111163 · NHLBI · WASHINGTON UNIVERSITY · PI SHARMA, VIJAY · 2012 to 2015
$1.5M
IMAGING FUNCTIONAL P-GLYCOPROTEIN TRANSPORT AT THE BBB IN ALZHEIMER'S DISEASER33AG033328 · NIA · WASHINGTON UNIVERSITY · PI SHARMA, VIJAY · 2009 to 2011
$1.1M
NCI NIH HHS P30 CA091842NCI NIH HHS P30 CA91842NCI NIH HHS P50 CA094056NCI NIH HHS P50 CA94056NHLBI NIH HHS R01 HL111163NIA NIH HHS R33 AG033328
6 · The paper itself

Abstract

Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.

Indexed as

AnimalsCell LineEthylenediaminesGallium RadioisotopesHumansMaleMCF-7 CellsMiceMyocardial Perfusion ImagingOrganometallic CompoundsPositron-Emission TomographyRadionuclide GeneratorsRadiopharmaceuticalsRatsRats, Sprague-DawleyEthylenediaminesGallium RadioisotopesOrganometallic CompoundsRadiopharmaceuticals

Identifiers

PMID25353349
PMCPMC4212944
OpenAlexW2099792420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.