ArticleMolecular metabolism2014
Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass.
Article in Molecular metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 52 citations in OpenAlex.
- Preliminary investigation of ghrelin in horses and ponies: receptor expression and associations with prandial state, morphometry and signalment.BMC veterinary research · 2026Article
- Ghrelin and LEAP2: Their Interaction Effect on Appetite Regulation and the Alterations in Their Levels Following Bariatric Surgery.Medicina (Kaunas, Lithuania) · 2025Review
- Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review.Frontiers in public health · 2025Review
- Obesity- and diet-induced plasticity in systems that control eating and energy balance.Obesity (Silver Spring, Md.) · 2024Review
- Impact of Resistance and Endurance Training on Ghrelin and Plasma Leptin Levels in Overweight and Obese Subjects.International journal of molecular sciences · 2024Review
- The intersection between ghrelin, metabolism and circadian rhythms.Nature reviews. Endocrinology · 2024Review
- Ghrelin deletion and conditional ghrelin cell ablation increase pancreatic islet size in mice.The Journal of clinical investigation · 2023Article
- Interventional metabology: A review of bariatric arterial embolization and endovascular denervation for treating metabolic disorders.Journal of diabetes · 2023Review
- Regulation of body weight: Lessons learned from bariatric surgery.Molecular metabolism · 2023Review
- Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation.Journal of inflammation research · 2023Review
- The expression and function of growth hormone secretagogue receptor in immune cells: A current perspective.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Does kisspeptin act as a neuropeptide or as an adipokine in obese people?Journal of Taibah University Medical Sciences · 2022Article
- Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome.Molecules (Basel, Switzerland) · 2021Article
- Article
- Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet.Journal of clinical medicine · 2021Review
- Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin.JCI insight · 2021Article
- Gastrointestinal peptides in eating-related disorders.Physiology & behavior · 2021 · on this mapReview
- Quercetin Ameliorates Insulin Resistance and Restores Gut Microbiome in Mice on High-Fat Diets.Antioxidants (Basel, Switzerland) · 2021Article
- The Function of Gastrointestinal Hormones in Obesity-Implications for the Regulation of Energy Intake.Nutrients · 2021Review
- ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.American journal of physiology. Endocrinology and metabolism · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels were altered in obesity and after weight loss through changes in ghrelin cell responsiveness to physiological cues. We confirmed lower ghrelin levels in DIO mice and demonstrated elevated ghrelin levels in mice 6 weeks post-RYGB. In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine. In DIO mice, increases in ghrelin cell density within both the stomach and duodenum and in somatostatin-immunoreactive D cell density in the duodenum were observed. Our findings provide new insights into the regulation of ghrelin secretion and its relation to circulating ghrelin within the contexts of obesity and weight loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.