Evidence map›Paper›PMID 25352908›Full record

ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2014

Canadian hereditary angioedema guideline.

Stephen Betschel, Jacquie Badiou, Karen Binkley, Jacques Hébert, Amin Kanani, Paul Keith, Gina Lacuesta, Bill Yang, Emel Aygören-Pürsün, Jonathan Bernstein and 23 more

Open access · goldAbstract read
In one paragraph

Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Comprehensive care for hereditary angioedema: lessons learned from HAEmophilia Treatment Centers.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Global frequency, diagnosis, and treatment of hereditary angioedema with normal C1 inhibitor.The journal of allergy and clinical immunology. Global · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Co-occurrence between C1 esterase inhibitor deficiency and autoimmune disease: a systematic literature review.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. The International/Canadian Hereditary Angioedema Guideline.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019
    Review
  16. Urticaria and angioedema.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018
    Review
  17. The Icatibant Outcome Survey: experience of hereditary angioedema management from six European countries.Journal of the European Academy of Dermatology and Venereology : JEADV · 2017
    Article
  18. Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 8 countries.

Stephen BetschelUniversity of Toronto, Toronto, Ontario Canada.
Jacquie BadiouHAE Canada, Notre Dame des Lourdes, Manitoba, Canada.
Karen BinkleyUniversity of Toronto, Toronto, Ontario Canada.
Jacques HébertDepartment of Medicine, Laval University, Quebec City, Quebec Canada.
Amin KananiDepartment of Medicine, University of British Columbia, Vancouver, British Columbia Canada.
Paul KeithDepartment of Medicine, McMaster University, Hamilton, Ontario Canada.
Gina LacuestaDepartment of Medicine, Dalhousie University, Halifax, Nova Scotia Canada.
Bill YangUniversity of Ottawa Medical School, Ottawa, Ontario Canada.
Emel Aygören-PürsünGoethe-Universität Frankfurt am Main, Frankfurt am Main, Germany.
Jonathan BernsteinDepartment of Internal Medicine, University of Cincinnati, Cincinnati, Ohio USA.
Konrad BorkDepartment of Dermatology, University Hospital of the Johannes Gutenberg-University of Mainz, Mainz, Germany.
Teresa CaballeroHospital La Paz Health Research Institute, Madrid, Spain.
Marco CicardiDepartment of Internal Medicine, UniversitadegliStudi di Milano, Ospedale L. Sacco, Milan, Italy.
Timothy CraigDepartments of Medicine and Pediatrics, Penn State University, Hershey, Pennsylvania USA.
Henriette Farkas3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Hilary LonghurstDepartment of Immunology, Barts and the London NHS Trust, London, England, UK.
Bruce ZurawUniversity of California, San Diego, San Diego, California USA.
Henrik BoysenHAE International, Skanderborg, Denmark.
Rozita Borici-MaziDepartment of Medicine, Queen's University, Kingston, Ontario Canada.
Tom BowenDepartments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta Canada.
Karen DallasSaskatoon Health Region, Saskatoon, Saskatchewan Canada.
John DeanBC Children's Hospital, Vancouver, British Columbia Canada.
Kelly Lang-RobertsonUniversity of Toronto, Toronto, Ontario Canada.
Benoît LaraméeCentre hospitalier de l'université de Montréal, Montréal, Quebec Canada.
Eric LeithDepartment of Medicine, University of Toronto, Oakville, Ontario Canada.
Sean MaceUniversity of Toronto, Toronto, Ontario Canada.
Christine McCuskerDepartment of Immunology, McGill University Health Centre, Montreal, Quebec Canada.
Bill MooteDepartment of Medicine, Western University, London, Ontario Canada.
Man-Chiu PoonSouthern Alberta Rare Blood and Bleeding Disorders Comprehensive Care Program, Calgary, Alberta Canada.
Bruce RitchieDepartments of Medicine and Medical Oncology, University of Alberta, Edmonton, Alberta Canada.
Donald StarkDepartment of Medicine, University of British Columbia, Vancouver, British Columbia Canada.
Gordon SussmanUniversity of Toronto, Toronto, Ontario Canada.
Susan WasermanDepartment of Medicine, McMaster University, Hamilton, Ontario Canada.
University of Toronto · CAUniversity of British Columbia · CAMcMaster University · CABarts Health NHS Trust · GBCentre Hospitalier de l’Université de Montréal · CADalhousie University · CAGoethe University Frankfurt · DEHospital La Paz Institute for Health Research · ESJohannes Gutenberg University Mainz · DEMcGill University Health Centre · CAPennsylvania State University · USQueen's University · CASemmelweis University · HUThermo Fisher Scientific (Denmark) · DKUniversité Laval · CAUniversity of Alberta · CAUniversity of Calgary · CAUniversity of California San Diego · USUniversity of Cincinnati · USUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary angioedema (HAE) is a disease which is associated with random and often unpredictable attacks of painful swelling typically affecting the extremities, bowel mucosa, genitals, face and upper airway. Attacks are associated with significant functional impairment, decreased Health Related Quality of Life, and mortality in the case of laryngeal attacks. Caring for patients with HAE can be challenging due to the complexity of this disease. The care of patients with HAE in Canada is neither optimal nor uniform across the country. It lags behind other countries where there are more organized models for HAE management, and where additional therapeutic options are licensed and available for use. The objective of this guideline is to provide graded recommendations for the management of patients in Canada with HAE. This includes the treatment of attacks, short-term prophylaxis, long-term prophylaxis, and recommendations for self-administration, individualized therapy, quality of life, and comprehensive care. It is anticipated that by providing this guideline to caregivers, policy makers, patients and their advocates, that there will be an improved understanding of the current recommendations regarding management of HAE and the factors that need to be considered when choosing therapies and treatment plans for individual patients. The primary target users of this guideline are healthcare providers who are managing patients with HAE. Other healthcare providers who may use this guideline are emergency physicians, gastroenterologists, dentists and otolaryngologists, who will encounter patients with HAE and need to be aware of this condition. Hospital administrators, insurers and policy makers may also find this guideline helpful.

Indexed as

Acute attacksComprehensive careGRADEGuidelineHereditary angioedemaIndividualized therapyLong-term prophylaxisQuality of lifeRecommendationsSelf-administrationShort-term prophylaxis

Identifiers

PMID25352908
PMCPMC4210625
OpenAlexW2121788941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.