ArticleFrontiers in cellular neuroscience2014
Use of induced pluripotent stem cell derived neurons engineered to express BDNF for modulation of stressor related pathology.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Neuroprotection Strategies for Term Encephalopathy.Seminars in pediatric neurology · 2019Review
- Induced pluripotent stem cells for neural drug discovery.Drug discovery today · 2019Review
- Pluripotent stem cells in neuropsychiatric disorders.Molecular psychiatry · 2017Review
- Induced Pluripotent Stem Cells in Huntington's Disease: Disease Modeling and the Potential for Cell-Based Therapy.Molecular neurobiology · 2016Review
- PSA-NCAM positive neural progenitors stably expressing BDNF promote functional recovery in a mouse model of spinal cord injury.Stem cell research & therapy · 2016Article
- IFN-γ differentially modulates memory-related processes under basal and chronic stressor conditions.Frontiers in cellular neuroscience · 2014Article
- The neuroimmune-neuroplasticity interface and brain pathology.Frontiers in cellular neuroscience · 2014Article
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Authors and funding
7 authors.
Funding
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Abstract
Combined cell and gene-based therapeutic strategies offer potential in the treatment of neurodegenerative and psychiatric conditions that have been associated with structural brain disturbances. In the present investigation, we used a novel virus-free re-programming method to generate induced pluripotent stem cells (iPSCs), and then subsequently transformed these cells into neural cells which over-expressed brain derived neurotrophic factor (BDNF). Importantly, the infusion of iPSC derived neural cells (as a cell replacement and gene delivery tool) and BDNF (as a protective factor) influenced neuronal outcomes. Specifically, intracerebroventricular transplantation of iPSC-derived neural progenitors that over-expressed BDNF reversed the impact of immune (lipopolysaccharide) and chronic stressor challenges upon subventricular zone adult neurogenesis, and the iPSC-derived neural progenitor cells alone blunted the stressor-induced corticosterone response. Moreover, our findings indicate that mature dopamine producing neurons can be generated using iPSC procedures and appear to be viable when infused in vivo. Taken together, these data could have important implications for using gene-plus-cell replacement methods to modulate stressor related pathology.
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Registered trials
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