ReviewFrontiers in neuroscience2014
Review: neuroestrogen regulation of socio-sexual behavior of males.
Review in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Brain Activation Patterns during Sexual Arousal: A Comparative Time-Course Functional Magnetic Resonance Imaging Study in Postoperative Female-to-Male Transgender Individuals, Cisgender Men, and Premenopausal Women.The world journal of men's health · 2026Article
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake.The FEBS journal · 2025Article
- Addressing Combative Behaviour in Spanish Bulls by Measuring Hormonal Indicators.Veterinary sciences · 2024Article
- Article
- Beyond a biased binary: A perspective on the misconceptions, challenges, and implications of studying females in avian behavioral endocrinology.Frontiers in physiology · 2022Article
- Neuroendocrine patterns underlying seasonal song and year-round territoriality in male black redstarts.Frontiers in zoology · 2021Article
- Sex-dimorphic neuroestradiol regulation of ventromedial hypothalamic nucleus glucoregulatory transmitter and glycogen metabolism enzyme protein expression in the rat.BMC neuroscience · 2020Article
- Soya bean rich diet is associated with adult male rat aggressive behavior: relation to RF amide-related peptide 3-aromatase-neuroestrogen pathway in the brain.Metabolic brain disease · 2019Article
- Puberty and the human brain: Insights into adolescent development.Neuroscience and biobehavioral reviews · 2018Review
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- Estradiol and the Development of the Cerebral Cortex: An Unexpected Role?Frontiers in neuroscience · 2018Review
- Dual Actions of Mammalian and Piscine Gonadotropin-Inhibitory Hormones, RFamide-Related Peptides and LPXRFamide Peptides, in the Hypothalamic-Pituitary-Gonadal Axis.Frontiers in endocrinology · 2017Article
- Ventromedial Hypothalamus and the Generation of Aggression.Frontiers in systems neuroscience · 2017Review
- Gonadotropin Inhibitory Hormone Down-Regulates the Brain-Pituitary Reproductive Axis of Male European Sea Bass (Dicentrarchus labrax).Biology of reproduction · 2016Article
- GnIH Control of Feeding and Reproductive Behaviors.Frontiers in endocrinology · 2016Review
- Avian Test Battery for the Evaluation of Developmental Abnormalities of Neuro- and Reproductive Systems.Frontiers in neuroscience · 2016Article
- Distinct Effects of Estrogen on Mouse Maternal Behavior: The Contribution of Estrogen Synthesis in the Brain.PloS one · 2016Article
- Utilizing induced pluripotent stem cells (iPSCs) to understand the actions of estrogens in human neurons.Hormones and behavior · 2015Review
- Direct Regulation of Aromatase B Expression by 17β-Estradiol and Dopamine D1 Receptor Agonist in Adult Radial Glial Cells.Frontiers in neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is thought that estrogen (neuroestrogen) synthesized by the action of aromatase in the brain from testosterone activates male socio-sexual behaviors, such as aggression and sexual behavior in birds. We recently found that gonadotropin-inhibitory hormone (GnIH), a hypothalamic neuropeptide, inhibits socio-sexual behaviors of male quail by directly activating aromatase and increasing neuroestrogen synthesis in the preoptic area (POA). The POA is thought to be the most critical site of aromatization and neuroestrogen action for the regulation of socio-sexual behavior of male birds. We concluded that GnIH inhibits socio-sexual behaviors of male quail by increasing neuroestrogen concentration beyond its optimal concentration in the brain for expression of socio-sexual behavior. On the other hand, it has been reported that dopamine and glutamate, which stimulate male socio-sexual behavior in birds and mammals, inhibit the activity of aromatase in the POA. Multiple studies also report that the activity of aromatase or neuroestrogen is negatively correlated with changes in male socio-sexual behavior in fish, birds, and mammals including humans. Here, we review previous studies that investigated the role of neuroestrogen in the regulation of male socio-sexual behavior and reconsider the hypothesis that neuroestrogen activates male socio-sexual behavior in vertebrates. It is considered that basal concentration of neuroestrogen is required for the maintenance of male socio-sexual behavior but higher concentration of neuroestrogen may inhibit male socio-sexual behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.