Evidence map›Paper›PMID 25352485›Full record

ArticleStroke2014

Polygenic overlap between kidney function and large artery atherosclerotic stroke.

Elizabeth G Holliday, Matthew Traylor, Rainer Malik, Stephen Bevan, Jane Maguire, Simon A Koblar, Jonathan Sturm, Graeme J Hankey, Christopher Oldmeadow, Mark McEvoy and 25 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Guideline
  2. Genetic Determinants of Left Atrial Function Are Associated With Stroke.Journal of the American Heart Association · 2024
    Article
  3. Article
  4. Review
  5. Impact of multimorbidity on risk and outcome of stroke: Lessons from chronic kidney disease.International journal of stroke : official journal of the International Stroke Society · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Cystatin C Predicts Incident Cardiovascular Disease in Twins.Journal of the American Heart Association · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 1 institution in 1 country.

Elizabeth G HollidayFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Matthew TraylorFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Rainer MalikFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Stephen BevanFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Jane MaguireFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Simon A KoblarFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Jonathan SturmFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Graeme J HankeyFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Christopher OldmeadowFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Mark McEvoyFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Cathie SudlowFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Peter M RothwellFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Josef CoreshFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Pavel HametFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Johanne TremblayFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Stephen T TurnerFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Mariza de AndradeFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Madhumathi RaoFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Reinhold SchmidtFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Peter A CrickFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Antonietta RobinoFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Carmen A PeraltaFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
J Wouter JukemaFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Paul MitchellFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Sylvia E RosasFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Jie Jin WangFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Rodney J ScottFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Martin DichgansFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Braxton D MitchellFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
W H Linda KaoFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Caroline S FoxFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Christopher LeviFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
John AttiaFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
Hugh S MarkusFrom the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho
CKDGen Consortium and the International Stroke Genetics Consortium
Hunter Medical Research Institute · AU

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3M
Framingham Heart Study/FoxZIAHL006094 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI FOX, CAROLINE · 2010 to 2015
$6.9M
NHLBI FAMILY BLOOD PRESSURE PROGRAM (GENOA)U01HL054464 · NHLBI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI TURNER, STEPHEN T · 2000 to 2004
$2.6M
Genetics of Chronic Kidney DiseaseR01DK073537 · NIDDK · MAYO CLINIC ROCHESTER · PI TURNER, STEPHEN T · 2006 to 2010
$2.4M
Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic GroupsU01HG004436 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2008 to 2009
$1.1M
Genetic Epidemiology of NAFLD and T2DMK01DK067207 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KAO, WEN HONG LINDA · 2005 to 2009
$642k
CIHRIntramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA HL006094NCATS NIH HHS UL1 TR000135NHGRI NIH HHS U01 HG004436NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL096812NIDDK NIH HHS K01 DK067207NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK073537Wellcome Trust 095626
6 · The paper itself

Abstract

background and purposeEpidemiological studies show strong associations between kidney dysfunction and risk of ischemic stroke (IS), the mechanisms of which are incompletely understood. We investigated whether these associations may reflect shared heritability because of a common polygenic basis and whether this differed for IS subtypes.

methodsPolygenic models were derived using genome-wide association studies meta-analysis results for 3 kidney traits: estimated glomerular filtration rate using serum creatinine (eGFRcrea: n=73 998), eGFR using cystatin C (eGFRcys: n=22 937), and urinary albumin to creatinine ratio (n=31 580). For each, single nucleotide polymorphisms passing 10 P value thresholds were used to form profile scores in 4561 IS cases and 7094 controls from the United Kingdom, Germany, and Australia. Scores were tested for association with IS and its 3 aetiological subtypes: large artery atherosclerosis, cardioembolism, and small vessel disease.

resultsPolygenic scores correlating with higher eGFRcrea were associated with reduced risk of large artery atherosclerosis, with 5 scores reaching P<0.05 (peak P=0.004) and all showing the epidemiologically expected direction of effect. A similar pattern was observed for polygenic scores reflecting higher urinary albumin to creatinine ratio, of which 3 associated with large artery atherosclerosis (peak P=0.01) and all showed the expected directional association. One urinary albumin to creatinine ratio-based score also associated with small vessel disease (P=0.03). The global pattern of results was unlikely to have occurred by chance (P=0.02).

conclusionsThis study suggests possible polygenic correlation between renal dysfunction and IS. The shared genetic components may be specific to stroke subtypes, particularly large artery atherosclerotic stroke. Further study of the genetic relationships between these disorders seems merited.

Indexed as

AlbuminuriaGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansKidney DiseasesPolymorphism, Single NucleotideStrokegenetic epidemiologykidneystroke

Identifiers

PMID25352485
PMCPMC4245455
OpenAlexW2168965054

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