ArticleBMC research notes2014
Growth differentiation factor 11 is an encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.
Article in BMC research notes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Novel insights into the pleiotropic health effects of growth differentiation factor 11 gained from genome-wide association studies in population biobanks.BMC genomics · 2024Article
- The role of miRNA molecules in the miscarriage process.Biology of reproduction · 2023Article
- The influence of GDF11 on brain fate and function.GeroScience · 2019Review
- MicroRNA expression profiling in placenta and maternal plasma in early pregnancy loss.Molecular medicine reports · 2018Article
- GDF11 Treatment Attenuates the Recovery of Skeletal Muscle Function After Injury in Older Rats.The AAPS journal · 2017Article
- Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function.PloS one · 2017Article
- Mimicking Neural Stem Cell Niche by Biocompatible Substrates.Stem cells international · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe central nervous system has a complex structural organization and consists of different subdomains along the antero-posterior axis. However, questions remain about the molecular mechanisms leading to the regionalization of this organ. We used a previously developed methodology to identify the novel patterning role of GDF11, a TGF-β signaling factor.
findingsUsing an assay based on neural differentiated mouse embryonic stem cells, GDF11 is shown to induce diencephalic (posterior forebrain), mesencephalic (midbrain) and metencephalic (anterior hindbrain) fates at the expense of telencephalic (anterior forebrain) specification. GDF11 has not previously been implicated in the early patterning of the nervous system. In addition, inhibition of the TGF-β type I receptors Alk4, Alk5 and Alk7 by the pharmacological inhibitor SB431542 caused a strong anteriorization of the cells.
conclusionsOur findings suggest that GDF11 is involved in the earliest steps of the brain patterning during neurogenesis in the vertebrate embryo and is shown to be a regionalizing factor of the regional fate in the developing brain. This regionalization is not a typical posteriorizing signal as seen with retinoic acid, FGF or BMP molecules. To our knowledge, this is the first time that GDF11 is implicated in the earliest steps of the patterning of the neural plate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.