ArticlePlant physiology2014
Promoter-based integration in plant defense regulation.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Comparative Transcriptomic Analysis Reveals the Underlying Mechanism ofPlants (Basel, Switzerland) · 2026Article
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Exploring the functional roles of secondary metabolites in Brassica defense networks.Journal of biosciences · 2026Review
- Creating a new oilseed crop, pennycress, by combining key domestication traits using CRISPR genome editing.Nature plants · 2026Article
- Article
- Novel Regulators and Their Epistatic Networks in Arabidopsis' Defence Responses to Alternaria alternata Infection.Molecular plant pathology · 2025Article
- Transcriptional activation ofFrontiers in plant science · 2025Article
- The RNA-Binding Protein BoRHON1 Positively Regulates the Accumulation of Aliphatic Glucosinolates in Cabbage.International journal of molecular sciences · 2024Article
- Chromosome-scale reference genome of broccoli (Horticulture research · 2024Article
- Defense strategies and associated phytohormonal regulation inFrontiers in plant science · 2024Review
- A Common Molecular Signature Indicates the Pre-Meristematic State of Plant Calli.International journal of molecular sciences · 2023Review
- Identification of new potential downstream transcriptional targets of the strigolactone pathway including glucosinolate biosynthesis.Plant direct · 2023Article
- Identification andFrontiers in plant science · 2023Article
- A genome-scale TF-DNA interaction network of transcriptional regulation of Arabidopsis primary and specialized metabolism.Molecular systems biology · 2021Article
- Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Integrative inference of transcriptional networks in Arabidopsis yields novel ROS signalling regulators.Nature plants · 2021Article
- Microarray analysis ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- A bipartite transcription factor module controlling expression in the bundle sheath of Arabidopsis thaliana.Nature plants · 2020Article
- Iron homeostasis and plant immune responses: Recent insights and translational implications.The Journal of biological chemistry · 2020Review
- Distinct defensive activity of phenolics and phenylpropanoid pathway genes in different cotton varieties toward chewing pests.Plant signaling & behavior · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key unanswered question in plant biology is how a plant regulates metabolism to maximize performance across an array of biotic and abiotic environmental stresses. In this study, we addressed the potential breadth of transcriptional regulation that can alter accumulation of the defensive glucosinolate metabolites in Arabidopsis (Arabidopsis thaliana). A systematic yeast one-hybrid study was used to identify hundreds of unique potential regulatory interactions with a nearly complete complement of 21 promoters for the aliphatic glucosinolate pathway. Conducting high-throughput phenotypic validation, we showed that >75% of tested transcription factor (TF) mutants significantly altered the accumulation of the defensive glucosinolates. These glucosinolate phenotypes were conditional upon the environment and tissue type, suggesting that these TFs may allow the plant to tune its defenses to the local environment. Furthermore, the pattern of TF/promoter interactions could partially explain mutant phenotypes. This work shows that defense chemistry within Arabidopsis has a highly intricate transcriptional regulatory system that may allow for the optimization of defense metabolite accumulation across a broad array of environments.
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