Observational studyInternational urology and nephrology2015
C-terminal agrin fragment (CAF) as a serum biomarker for residual renal function in peritoneal dialysis patients.
Observational study in International urology and nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02346968 (Evaluation of Serum and Urinary C-terminal Agrin Fragment-22), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Serum and Urinary C-terminal Agrin Fragment-22 (CAF22) as Novel Renal Function Marker in Kidney Transplant Recipients - A Prospective Observational Study
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Serum β2-microglobulin as a predictor of residual kidney function in peritoneal dialysis patients.Journal of nephrology · 2021Article
- Plasma C-terminal agrin fragment and rapid kidney function decline in chronic kidney disease patients.Medicine · 2019Observational
- Measurement and Estimation of Residual Kidney Function in Patients on Dialysis.Advances in chronic kidney disease · 2018Review
- C-terminal fragment of agrin (CAF) levels predict acute kidney injury after acute myocardial infarction.BMC nephrology · 2017Observational
- The Reference Intervals for Serum C-Terminal Agrin Fragment in Healthy Individuals and as a Biomarker for Renal Function in Kidney Transplant Recipients.Journal of clinical laboratory analysis · 2017Article
- Advances in Understanding and Management of Residual Renal Function in Patients with Chronic Kidney Disease.Kidney diseases (Basel, Switzerland) · 2017Review
- Estimating residual kidney function in dialysis patients without urine collection.Kidney international · 2016Article
- Article
- C-Terminal Fragment of Agrin (CAF): A Novel Marker for Progression of Kidney Disease in Type 2 Diabetics.PloS one · 2015Observational
- Development and Validation of Residual Kidney Function Estimating Equations in Dialysis Patients.Kidney medicineArticle
- A Review of Residual Kidney Function in Peritoneal Dialysis Patients.Indian journal of nephrologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundC-terminal agrin fragment (CAF, size 22 kDa) is a promising new biomarker for kidney function. This study evaluated the usefulness of CAF as a serum biomarker for residual renal function (RRF) in patients undergoing automated peritoneal dialysis (APD). PATIENTS AND
methodsSerum, urine and dialysate samples were obtained in 12 end-stage renal disease patients undergoing APD. Total, renal and peritoneal clearances were calculated for CAF, creatinine, blood urea nitrogen (BUN) and cystatin c. kt/V was computed, and RRF (in ml/min) was calculated as the arithmetic mean of creatinine and BUN clearance. Correlations between the biomarkers' serum concentrations, clearances, kt/V and RRF were computed.
resultsSerum CAF concentrations were highly correlated with serum concentrations of creatinine (r = 0.806, p = 0.002), BUN (r = 0.727, p = 0.007), cystatin c (r = 0.839, p = 0.001) and inversely to 24-h urinary output (r = -0.669, p = 0.017). RRF was inversely correlated with serum concentrations of CAF, cystatin c and creatinine being highest for CAF (r = -0.734, p = 0.007) followed by cystatin c (r = -0.65, p = 0.022) and creatinine (r = -0.606, p = 0.037). Serum BUN was not significantly associated with RRF (r = -0.497, p = 0.101). Age, weight and gender did not significantly affect serum CAF concentrations.
conclusionSerum CAF provides a robust serum biomarker for RRF in peritoneal dialysis patients undergoing APD, possibly outperforming the value of conventional biomarkers.
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