ArticleBrain pathology (Zurich, Switzerland)2015
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease.
Article in Brain pathology (Zurich, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer's disease.Acta neuropathologica communications · 2022Article
- Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.Scientific reports · 2021Article
- Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms.Annual review of genetics · 2021Review
- "Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress.Neurobiology of stress · 2021Article
- Ocular Health ofFrontiers in integrative neuroscience · 2021Article
- Disruption of Glucose Metabolism in AgedFrontiers in integrative neuroscience · 2021Article
- WNT Signaling Is a Key Player in Alzheimer's Disease.Handbook of experimental pharmacology · 2021Article
- Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus.Scientific reports · 2020Article
- In situ structural characterization of early amyloid aggregates in Alzheimer's disease transgenic mice and Octodon degus.Scientific reports · 2020Article
- Riluzole: a therapeutic strategy in Alzheimer's disease by targeting the WNT/β-catenin pathway.Aging · 2020Article
- Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus.Molecular neurobiology · 2020Article
- Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus.Frontiers in neuroscience · 2020Article
- Wnt Signaling Pathway Dysregulation in the Aging Brain: Lessons From theFrontiers in cell and developmental biology · 2020Article
- Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus.Molecular neurobiology · 2018Article
- Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.Scientific reports · 2017Article
- Identification of Cerebral Metal Ion Imbalance in the Brain of AgingFrontiers in aging neuroscience · 2017Article
- Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2017Article
- Actin dynamics and cofilin-actin rods in alzheimer disease.Cytoskeleton (Hoboken, N.J.) · 2016Review
- Revisiting rodent models: Octodon degus as Alzheimer's disease model?Acta neuropathologica communications · 2016Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the leading cause of age-related dementia worldwide. Several models for AD have been developed to provide information regarding the initial changes that lead to degeneration. Transgenic mouse models recapitulate many, but not all, of the features of AD, most likely because of the high complexity of the pathology. In this context, the validation of a wild-type animal model of AD that mimics the neuropathological and behavioral abnormalities is necessary. In previous studies, we have reported that the Chilean rodent Octodon degus could represent a natural model for AD. In the present work, we further describe the age-related neurodegeneration observed in the O. degus brain. We report some histopathological markers associated with the onset progression of AD, such as glial activation, increase in oxidative stress markers, neuronal apoptosis and the expression of the peroxisome proliferative-activated receptor γ coactivator-1α (PGC-1α). With these results, we suggest that the O. degus could represent a new model for AD research and a powerful tool in the search for therapeutic strategies against AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.