ArticleScientific reports2014
Reversal of anchorage-independent multicellular spheroid into a monolayer mimics a metastatic model.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Mimicking the Complexity of Solid Tumors: How Spheroids Could Advance Cancer Preclinical Transformative Approaches.Cancers · 2025Article
- Spheroid Model of Mammary Tumor Cells: Epithelial-Mesenchymal Transition and Doxorubicin Response.Biology · 2024Article
- Inhibitory Effect of Ursolic Acid on the Migration and Invasion of Doxorubicin-Resistant Breast Cancer.Molecules (Basel, Switzerland) · 2022Article
- The matrix-dependent 3D spheroid model of the migration of non-small cell lung cancer: a step towards a rapid automated screening.Frontiers in molecular biosciences · 2021Article
- Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators.Frontiers in oncology · 2021Article
- Article
- Cell Type-Specific TGF-β Mediated EMT in 3D and 2D Models and Its Reversal by TGF-β Receptor Kinase Inhibitor in Ovarian Cancer Cell Lines.International journal of molecular sciences · 2019Article
- miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism.Cancer research · 2019Article
- Investigation of multicellular tumor spheroids enriched for a cancer stem cell phenotype.Stem cell investigation · 2019Article
- Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma.BMC cancer · 2018Article
- SOX2, a stemness gene, induces progression of NSCLC A549 cells toward anchorage-independent growth and chemoresistance to vinblastine.OncoTargets and therapy · 2018Article
- Inherent aggressive character of invasive and non-invasive cells dictates the in vitro migration pattern of multicellular spheroid.Scientific reports · 2017Article
- Increased matrix stiffness promotes tumor progression of residual hepatocellular carcinoma after insufficient heat treatment.Cancer science · 2017Article
- Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma.Oncotarget · 2017Article
- Multicellular tumor spheroids of human uveal melanoma induce genes associated with anoikis resistance, lipogenesis, and SSXs.Molecular vision · 2017Article
- Sialylation facilitates self-assembly of 3D multicellular prostaspheres by using cyclo-RGDfK(TPP) peptide.OncoTargets and therapy · 2017Article
- Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity.Breast cancer (Dove Medical Press) · 2017Review
- Sialylation transmogrifies human breast and pancreatic cancer cells into 3D multicellular tumor spheroids using cyclic RGD-peptide induced self-assembly.Oncotarget · 2016Article
- Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine Based on 3D Tumor Models.Molecules (Basel, Switzerland) · 2016Article
- Generation of a monoclonal antibody recognizing the CEACAM glycan structure and inhibiting adhesion using cancer tissue-originated spheroid as an antigen.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Lack of an in vitro model of metastasis has been a major impediment in understanding the molecular regulation of metastatic processes, and identification of specific therapeutic targets. We have established an in vitro model which displayed the signatures of metastatic phenotype such as migration, invasiveness, chemoresistance and expression of cancer stem-cell markers. This in vitro model was developed by the induction of reversal of multicellular spheroids that were generated by anchorage-independent growth. In vivo data further validated the metastatic phenotype of the in vitro model. Besides delineating the molecular events of metastasis, this model could also improve the screening efficiency of antimetastatic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.