Evidence map›Paper›PMID 25351805›Full record

Trial reportMolecular nutrition & food research2015

Soy provides modest benefits on endothelial function without affecting inflammatory biomarkers in adults at cardiometabolic risk.

Elizabeth J Reverri, Colette D LaSalle, Adrian A Franke, Francene M Steinberg

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Observational
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. The Antioxidant Role of Soy and Soy Foods in Human Health.Antioxidants (Basel, Switzerland) · 2020
    Review
  17. Article
  18. Article
  19. Review
  20. Legume Consumption and Cardiometabolic Health.Advances in nutrition (Bethesda, Md.) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Elizabeth J ReverriDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Colette D LaSalle
Adrian A Franke
Francene M Steinberg
University of California, Davis · USTufts University · USUniversity of Hawaiʻi at Mānoa · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
MASS SPECT SYST: SOY PHYTOESTROGEN &CARDIOVASCULAR EFFECTS, ATHEROSCLEROSISS10RR020890 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI FRANKE, ADRIAN A · 2005 to 2005
$421k
NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA71789NCRR NIH HHS S10 RR020890
6 · The paper itself

Abstract

scopeSystemic inflammation, endothelial dysfunction, and oxidative stress are involved in the pathogenesis of the metabolic syndrome (MetS). Epidemiological evidence supports an association between whole soy food consumption and reduced risk of cardiovascular disease (CVD). The objective of this randomized, controlled, cross-over study was to evaluate the effects of soy nut consumption on inflammatory biomarkers and endothelial function and to assess whether isoflavone metabolism to secondary products, equol, and/or O-desmethylangolensin (ODMA), modifies these responses. METHODS AND

resultsn = 17 adults at cardiometabolic risk were randomly assigned to the order of two snack interventions, soy nuts, and macronutrient-matched control snack, for four weeks each, separated by a two week washout period. Outcome measures included biomarkers of inflammation, oxidative stress, and glycemic control (ELISA and clinical analyzers), endothelial function, and arterial stiffness (peripheral arterial tonometry (PAT)), and isoflavone metabolites (LC-MS/MS). Results revealed that consuming soy nuts improved arterial stiffness as assessed by the augmentation index using PAT (p = 0.03), despite lack of improvement in inflammatory biomarkers. Addition of equol and/or ODMA production status as covariates did not significantly change these results.

conclusionSoy nuts when added to a usual diet for one month provide some benefit on arterial stiffness in adults at cardiometabolic risk.

Indexed as

DietBiomarkersBlood GlucoseCardiovascular DiseasesChromatography, LiquidCross-Over StudiesDiet RecordsEndotheliumEnzyme-Linked Immunosorbent AssayEquolFemaleGlycine maxHumansInflammationIsoflavonesMaleBiomarkersBlood GlucoseEquolIsoflavonesO-desmethylangolensinCardiometabolic riskEndothelial functionInflammationIsoflavoneSoy

Identifiers

PMID25351805
PMCPMC4451218
OpenAlexW1966171790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.