Trial reportEuropean journal of applied physiology2015
The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.
Trial report in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Extracellular Buffering Supplements to Improve Exercise Capacity and Performance: A Comprehensive Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Effects of Sodium Bicarbonate Supplementation on Muscular Strength and Endurance: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Influence of prior alkalosis or acidosis on physiological responses during passive hyperthermia.Experimental physiology · 2026Trial
- Fatigability of the knee extensors following high- and low-load resistance exercise sessions in trained men.European journal of applied physiology · 2022Trial
- Trial
- Common questions and misconceptions of sodium bicarbonate as an ergogenic aid: what does the science really show?Journal of the International Society of Sports Nutrition · 2026Review
- International Society of Sports Nutrition position stand: sodium bicarbonate and exercise performance.Journal of the International Society of Sports Nutrition · 2021Review
- Acute Effect of Sodium Bicarbonate Supplementation on Symptoms of Gastrointestinal Discomfort, Acid-Base Balance, and Performance of Jiu-Jitsu Athletes.Journal of human kinetics · 2020Article
- Changes in the quadriceps spinal reflex pathway after repeated sprint cycling are not influenced by ischemic preconditioning.European journal of applied physiology · 2020Article
- Passive heating following the prematch warm-up in soccer: examining the time-course of changes in muscle temperature and contractile function.Physiological reports · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study examined whether changes in pH throughout the physiologic range would have a differential effect on central and peripheral factors associated with fatigue and force production during submaximal lower limb isometric exercise to task failure.
methodsEight males completed three experimental trials [0.2 g kg(-1) ammonia chloride (ACD); 0.3 g kg(-1) calcium carbonate (PLA); or 0.3 g kg(-1) sodium bicarbonate (ALK)], each consisting of submaximal calf contractions at 55% of maximal voluntary contraction (MVC) to task failure. Every minute of the task subjects performed an MVC, coupled with stimulation of the tibial nerve during and immediately post MVC.
resultsTime to task failure was not different between trials (ACD 531 ± 166 s, PLA 592 ± 163 s, ALK 596 ± 150 s; p = 0.31). MVC force in all trials declined 29 % from the start of exercise to the fifth minute (mean decline of 371 ± 26 N; p < 0.001), however was not different between trials (p = 0.21). Fatigue was mediated in all trials by central and peripheral factors, as declines in voluntary activation, V/M-wave in the soleus and the potentiated resting twitch amplitudes were evident throughout the task (p < 0.05). Central fatigue appeared to be muscle specific, as reductions in central drive (V/M-wave and rate of sEMG rise) persisted in the soleus but not the medial gastrocnemius.
conclusionsThese data suggest that calf fatigue associated with intermittent, isometric contractions to task failure is unaffected by alterations in pH; however, central drive reductions may be muscle specific.
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Registered trials
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