Evidence map›Paper›PMID 25351746›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2015

Immunomodulatory antibody therapy of cancer: the closer, the better.

Roxana S Dronca, Haidong Dong

Open access · bronzeAbstract readComment
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Starting the fight in the tumor: expert recommendations for the development of human intratumoral immunotherapy (HIT-IT).Annals of oncology : official journal of the European Society for Medical Oncology · 2018
    Article
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  4. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Roxana S DroncaDivision of Medical Oncology, College of Medicine, Mayo Clinic, Rochester, Minnesota.
Haidong DongDepartment of Urology, College of Medicine, Mayo Clinic, Rochester, Minnesota. Department of Immunology, College of Medicine, Mayo Clinic, Rochester, Minnesota. dong.haidong@mayo.edu.
Mayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesKL2TR000136 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$6.6M
Functional B7-H1 expressed by T cellsR01AI095239 · NIAID · MAYO CLINIC ROCHESTER · PI DONG, HAIDONG · 2014 to 2018
$2.0M
Clinical Impact of B7-H Immune Cell Coregulators in Renal Cell CarcinomaR01CA134345 · NCI · MAYO CLINIC ROCHESTER · PI DONG, HAIDONG, KWON, EUGENE D. · 2009 to 2014
$1.5M
NCATS NIH HHS KL2 TR000136NCATS NIH HHS TR000136NCI NIH HHS R01 CA134345NCI NIH HHS R01CA134345NIAID NIH HHS R01 AI095239NIAID NIH HHS R01AI095239
6 · The paper itself

Abstract

Immune checkpoint blockade therapies have demonstrated promising therapeutic effects; however, clinical outcomes are variable, with only a subgroup of cancer patients achieving durable complete responses. New therapeutic strategies, including local administration of immunomodulatory antibodies, have been considered as better routes for improving the overall efficacy of antibody-based therapy.

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsCD40 AntigensFemaleHumansImmunologic FactorsMaleNeoplasmsT-LymphocytesUrinary Bladder NeoplasmsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsCD40 AntigensImmunologic Factorsmitazalimab

Identifiers

PMID25351746
PMCPMC4348171
OpenAlexW2048725732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.