Evidence map›Paper›PMID 25351497›Full record

ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2016

Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance.

Alfio Ferlito, Alessandra Rinaldo, Justin A Bishop, Jennifer L Hunt, Vincent Vander Poorten, Michelle D Williams, Asterios Triantafyllou, Kenneth O Devaney, Douglas R Gnepp, Kimihide Kusafuka and 4 more

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Guideline
  2. Neuroendocrine Tumors (NETs) of the Larynx.Diagnostics (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Non-conventional laryngeal malignancies: a multicentre review of management and outcomes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  7. Development of head and neck pathology in Europe.Virchows Archiv : an international journal of pathology · 2022
    Review
  8. Article
  9. Article
  10. Rare Diseases of Larynx, Trachea and Thyroid.Laryngo- rhino- otologie · 2021
    Review
  11. Review
  12. Review
  13. Should patients with laryngeal small cell neuroendocrine carcinoma receive prophylactic cranial irradiation?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 6 countries.

Alfio FerlitoUniversity of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy. a.ferlito@uniud.it.
Alessandra RinaldoUniversity of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy.
Justin A BishopDepartments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Jennifer L HuntDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Vincent Vander PoortenOtorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals KU Leuven, Leuven, Belgium.
Michelle D WilliamsDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Asterios TriantafyllouOral Pathology School of Dentistry, University of Liverpool, Liverpool, UK.
Kenneth O DevaneyDepartment of Pathology, Allegiance Health, Jackson, MI, USA.
Douglas R GneppHead and Neck Pathology, CBLPath, Warwick, RI, USA.
Kimihide KusafukaPathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.
Gyorgy B HalmosDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
William H WestraDepartments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Robert P TakesDepartment of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Lester D R ThompsonDepartment of Pathology, Woodland Hills Medical Center, Woodland Hills, CA, USA.
Johns Hopkins University · USHenry Ford Allegiance Health · USKU Leuven · BERadboud University Medical Center · NLShizuoka Cancer Center · JPThe University of Texas MD Anderson Cancer Center · USUniversity Medical Center Groningen · NLUniversity of Arkansas for Medical Sciences · USUniversity of Liverpool · GBUniversity of Udine · ITWoodland Hills Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx.

Indexed as

Carcinoma, NeuroendocrineHumansInappropriate ADH SyndromeLambert-Eaton Myasthenic SyndromeLaryngeal NeoplasmsMalignant Carcinoid SyndromeParaneoplastic SyndromesPrognosisDiagnosisLarynxNeuroendocrine carcinomasParaneoplastic syndromesPrognosis

Identifiers

PMID25351497
OpenAlexW2053276821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.