Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015
Brief versions of the FACIT-fatigue and FAACT subscales for patients with non-small cell lung cancer cachexia.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01387282 (Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): A Randomized Double-Blind Placebo-Controlled Multicenter Phase III Study to Evaluate the Safety and Efficacy of Anamorelin HCl in Patients With NSCLC-C
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Measuring health-related quality of life in patients with advanced cancer: a systematic review of self-administered measurement instruments.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Pooled it
- The Feasibility of a Co-Designed Online Healthy Living Intervention for Cancer Survivors: Valuable Content, But Limited Engagement.Psycho-oncology · 2026Article
- Article
- Efficacy and safety of neoadjuvant nab-paclitaxel plus gemcitabine therapy in patients with borderline resectable pancreatic cancer: A multicenter single-arm phase II study (NAC-GA trial).Annals of gastroenterological surgery · 2023Article
- Stress prediction using micro-EMA and machine learning during COVID-19 social isolation.Smart health (Amsterdam, Netherlands) · 2022Article
- Fatigue and Sleep Disturbance among Breast Cancer Patients during Treatment in Saudi Arabia.Nursing research and practice · 2022Article
- Article
- Impact ofCurrent therapeutic research, clinical and experimental · 2020Article
- Quality of life and anorexia/cachexia in lung cancer: validation of the Spanish version of the FAACT instrument.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Development and validation of a clinically applicable score to classify cachexia stages in advanced cancer patients.Journal of cachexia, sarcopenia and muscle · 2018Article
- Prospective validation of patient fatigue questionnaire (FACIT-F) for fatigue assessment in nab-paclitaxel plus gemcitabine therapy.Molecular and clinical oncology · 2018Article
- Validation of the Chinese version of functional assessment of anorexia-cachexia therapy (FAACT) scale for measuring quality of life in cancer patients with cachexia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Integrated Palliative Care and Oncologic Care in Non-Small-Cell Lung Cancer.Current treatment options in oncology · 2016Review
- Systematic content evaluation and review of measurement properties of questionnaires for measuring self-reported fatigue among older people.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- The Functional Assessment of Chronic Illness Therapy-Fatigue Measure: Cross-Cultural Validation of an Arabic Version for Older Jordanians.Iranian journal of nursing and midwifery researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeCancer anorexia-cachexia syndrome (CACS) is common in advanced cancer patients and associated with weight loss, fatigue, impaired quality of life (QoL), and poor prognosis. The goal of this project was to identify the most responsive items from two QoL measures in the ROMANA 2 (NCT01387282) phase III global study evaluating anamorelin HCl in the treatment of non-small cell lung cancer (NSCLC) cachexia: the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and the Functional Assessment of Anorexia/Cachexia Therapy (FAACT).
methodsIn the ROMANA 2 trial, 477 patients with unresectable stage III or IV NSCLC and cachexia were to be enrolled and randomized (2:1) to receive anamorelin HCl or placebo once daily for 12 weeks. All 203 patients who reached the week 12 visit at the time of data analysis were included. Co-primary endpoints were change from baseline in lean body mass and handgrip strength. QoL was a secondary outcome with FACIT-F and FAACT questionnaires administered at baseline and at weeks 3, 6, 9, and 12.
resultsTwo 4-item scales (fatigue/activity and appetite/eating) from the FACIT-F and FAACT questionnaires, respectively, demonstrated good internal consistency reliability, validity, and responsiveness (also referred to as the Simplified Evaluation of Fatigue (SEF) and Simplified Evaluation of Appetite (SEA), respectively). The estimated important difference for each scale was 1-2 points.
conclusionsThese brief scales provide the psychometric properties necessary to promote future research in NSCLC patients with CACS. Additional work should examine the clinical utility of these scales and their impact on treatment decision-making.
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