Observational studyClinical research in cardiology : official journal of the German Cardiac Society2015
Elevated M2-muscarinic and β1-adrenergic receptor autoantibody levels are associated with paroxysmal atrial fibrillation.
Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The Immune System as a Proarrhythmic Mediator: A Novel Paradigm for the Development of New Antiarrhythmic Therapy.The Canadian journal of cardiology · 2026Review
- B cells promote atrial fibrillation via autoantibodies.Nature cardiovascular research · 2025Article
- Autoimmune antibodies in arrhythmia: a narrative review of potential therapeutic targets to prevent overtreatment.Cardiovascular diagnosis and therapy · 2025Review
- Review
- βJournal of cardiovascular development and disease · 2023Review
- Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models.Clinical science (London, England : 1979) · 2023Article
- Autoantibodies in Atrial Fibrillation-State of the Art.International journal of molecular sciences · 2023Review
- Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease.Frontiers in physiology · 2023Review
- Immune remodeling and atrial fibrillation.Frontiers in physiology · 2022Review
- The Role of Autoantibodies in Arrhythmogenesis.Current cardiology reports · 2020Review
- Diagnostic and prognostic value of autoantibodies against βExperimental and therapeutic medicine · 2020Article
- Elevated β1-Adrenergic Receptor Autoantibody Levels Increase Atrial Fibrillation Susceptibility by Promoting Atrial Fibrosis.Frontiers in physiology · 2020Article
- Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients.Cardiology research and practice · 2019Article
- Baseline serum globulin as a predictor of the recurrence of lone atrial fibrillation after radiofrequency catheter ablation.Anatolian journal of cardiology · 2017Article
- Association of Serum Omentin-1 Concentrations with the Presence of Atrial Fibrillation.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Monocyte-platelet aggregates and CD11b expression as markers for thrombogenicity in atrial fibrillation.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- A peptidomimetic inhibitor suppresses the inducibility of β1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015Article
- Atrial fibrillation and long-term sports practice: epidemiology and mechanisms.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Review
- Lone AF: is There a Rationale?Journal of atrial fibrillationReview
- COMPARISON OF CARDIAC ARRHYTHMIA TYPES BETWEEN HYPERTHYROID PATIENTS WITH GRAVES' DISEASE AND TOXIC NODULAR GOITER.Acta endocrinologica (Bucharest, Romania : 2005)Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPathophysiologic mechanisms underlying lone atrial fibrillation (AF) have not been clearly demonstrated yet. Emerging evidence has indicated that autoimmunity may play a role in the development of AF. Relationship between serum anti-M2-muscarinic receptor autoantibody (anti-M2-R) and anti-β1-adrenergic receptor autoantibody (anti-β1-R) levels and lone paroxysmal atrial fibrillation (PAF) has not been investigated. We aimed to compare anti-M2-R and anti-β1-R levels between lone PAF patients and healthy control subjects. METHODS AND
results75 patients with lone PAF (age: 52.80 ± 6.80 years, 53 % male) and 75 healthy control subjects (age: 53.30 ± 6.80 years, 54 % male) were enrolled in the study. Serum anti-M2-R and anti-β1-R levels were measured by ELISA and compared between two groups. Anti-M2-R [142.30 (77.65-400.00) vs. 69.00 (39.48-299.04) ng/mL; p < 0.001) and anti-β1-R [102.56 (65.18-348.41) vs. 44.17 (30.89-158.54) ng/mL; p < 0.001] levels were significantly higher in patients with lone PAF compared to healthy controls. Multivariate regression analysis showed that left atrial diameter (OR: 1.471, p < 0.001), hs-CRP(OR: 1.940, p < 0.001), anti-M2-R (OR: 1.158, p < 0.001) and anti-β1-R (OR: 1.296, p < 0.001) levels were independent predictors for the presence of lone PAF. Using a cut-off level of 101.83 ng/mL, anti-M2-R levels predicted presence of lone PAF with a sensitivity of 94.68 % and specificity of 81.33 %. Anti-β1-R levels predicted presence of lone PAF with a sensitivity of 92.00 % and specificity of 73.30 %, using a cut-off level of 72.16 ng/mL.
conclusionOur results demonstrated that higher serum anti-M2-R and anti-β1-R levels are associated with lone PAF. Autoantibodies related to autonomic system may play an important role in the development of lone AF.
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