Evidence map›Paper›PMID 25351237›Full record

Trial reportBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2015

Prevention of etomidate-induced myoclonus during anesthetic induction by pretreatment with dexmedetomidine.

H F Luan, Z B Zhao, J Y Feng, J Z Cui, X B Zhang, P Zhu, Y H Zhang

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

H F LuanDepartment of Anesthesia, The First People's Hospital of Lianyungang, China.
Z B ZhaoDepartment of Anesthesia, The First People's Hospital of Lianyungang, China.
J Y FengDepartment of Anesthesia, The First People's Hospital of Lianyungang, China.
J Z CuiDepartment of Anesthesia, The First People's Hospital of Lianyungang, China.
X B ZhangDepartment of Anesthesia, The First People's Hospital of Lianyungang, China.
P ZhuDepartment of Anesthesia, The First People's Hospital of Lianyungang, China.
Y H ZhangDepartment of Anesthesia, The First People's Hospital of Lianyungang, China.
The First People’s Hospital of Lianyungang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myoclonus induced by etomidate during induction of general anesthesia is undesirable. This study evaluated the effect of dexmedetomidine (DEX) pretreatment on the incidence and severity of etomidate-induced myoclonus. Ninety patients undergoing elective surgical procedures were randomly allocated to three groups (n=30 each) for intravenous administration of 10 mL isotonic saline (group I), 0.5 µg/kg DEX in 10 mL isotonic saline (group II), or 1.0 µg/kg DEX in 10 mL isotonic saline (group III) over 10 min. All groups subsequently received 0.3 mg/kg etomidate by intravenous push injection. The incidence and severity of myoclonus were recorded for 1 min after etomidate administration and the incidence of cardiovascular adverse events that occurred between the administration of the DEX infusion and 1 min after tracheal intubation was recorded. The incidence of myoclonus was significantly reduced in groups II and III (30.0 and 36.7%), compared with group I (63.3%). The incidence of severe sinus bradycardia was significantly increased in group III compared with group I (P<0.05), but there was no significant difference in heart rate in groups I and II. There were no significant differences in the incidence of low blood pressure among the 3 groups. Pretreatment with 0.5 and 1.0 µg/kg DEX significantly reduced the incidence of etomidate-induced myoclonus during anesthetic induction; however, 0.5 µg/kg DEX is recommended because it had fewer side effects.

Indexed as

AdultAnesthetics, GeneralBlood PressureBradycardiaDexmedetomidineElective Surgical ProceduresEtomidateFemaleHeart RateHumansHypnotics and SedativesIncidenceMaleMiddle AgedMyoclonusSeverity of Illness IndexAnesthetics, GeneralDexmedetomidineEtomidateHypnotics and Sedatives

Identifiers

PMID25351237
PMCPMC4321226
OpenAlexW2126216563

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.