ReviewJournal of Alzheimer's disease : JAD2014
Arterial stiffness and cognitive function in the elderly.
Review in Journal of Alzheimer's disease : JAD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- The Impact of Cocoa Flavanols in Modulating Resting Cerebral Blood Flow During Prolonged Sitting in Healthy Young and Older Adults.Nutrients · 2025Trial
- One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Trial
- Effects and Correction of Patient Bulk Motion in Cranial DENSE MRI.Magnetic resonance in medicine · 2026Article
- Gender-dependent association between cardiovascular health and cognitive function in chinese older adults: a community based cohort study.Cerebral circulation - cognition and behavior · 2026Article
- Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function.The Journal of nutrition · 2025Article
- Reduced removal of waste products from energy metabolism takes center stage in human brain aging.Scientific reports · 2025Article
- Should regression calibration or multiple imputation be used when calibrating different devices in a longitudinal study?American journal of epidemiology · 2025Article
- Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol.Frontiers in aging neuroscience · 2025Article
- Association between fibrosis-4 index and cognitive impairment in elderly patients with hypertension: A cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Association between arterial health and cognition in adolescents: The PANIC study.Physiological reports · 2024Article
- Optimal cardiovascular health is associated with slower cognitive decline.European journal of neurology · 2024Article
- Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging.Frontiers in neuroendocrinology · 2023Review
- Correlation between ankle-brachial index and subtle cognitive decline.Brain and behavior · 2023Article
- Arterial stiffness and its influence on cerebral morphology and cognitive function.Therapeutic advances in neurological disorders · 2023Article
- Influencing Factors and Exercise Intervention of Cognitive Impairment in Elderly Patients with Chronic Obstructive Pulmonary Disease.Clinical interventions in aging · 2020Review
- A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis.Disease markers · 2019Article
- The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study.Clinical endocrinology · 2017Article
- Cognitive Impairment in Chronic Kidney Disease: Vascular Milieu and the Potential Therapeutic Role of Exercise.BioMed research international · 2017Review
- Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia: The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS).Journal of Alzheimer's disease : JAD · 2017Article
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cognitive decline and dementia are a major cause of disability and mortality among older adults. Cross-sectional evidence from observational studies suggests that greater arterial stiffness is associated with worse cognitive performance. These associations have been observed on measures of global cognition and across multiple domains of cognition. Epidemiologic evidence on the association between arterial stiffness and rate of cognitive decline has been less definitive, and very few studies have investigated the risk of developing dementia. This review summarizes the current research on arterial stiffness and cognition, issues around measurement, and the effect that potential intervention might have on the course of cognitive aging. The evidence on pharmacological and non-pharmacological (exercise, nutrition, etc.) interventions in older adults with arterial stiffness is promising. Yet there are no studies or trials that directly evaluate how interventions of arterial stiffness reduce or prevent cognitive impairment and risk of developing dementia. More research is needed to elucidate the causal link between arterial stiffness and cognitive decline and dementia, and to identify whether potential interventions to prevent or reduce arterial stiffness may benefit cognitive health of the elderly.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.