ArticlePloS one2014
CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Immune Activation Following Spinal Cord Injury: A Review Focused on Inflammatory Changes in the Spinal Cord.International journal of molecular sciences · 2025Review
- The role of foam cells in spinal cord injury: challenges and opportunities for intervention.Frontiers in immunology · 2024Review
- Subacute and Chronic Spinal Cord Injury: A Scoping Review of Epigenetics and Secondary Health Conditions.Epigenetics insights · 2023Article
- Oxidative DNA Damage in the Pathophysiology of Spinal Cord Injury: Seems Obvious, but Where Is the Evidence?Antioxidants (Basel, Switzerland) · 2022Review
- Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection?Frontiers in molecular biosciences · 2022Review
- Cerebrospinal fluid and peripheral blood proteomics in Traumatic Spinal Cord Injury: A prospective pilot study.Brain & spine · 2022Article
- Multi-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation.International journal of molecular sciences · 2021Article
- Nusinersen Modulates Proteomics Profiles of Cerebrospinal Fluid in Spinal Muscular Atrophy Type 1 Patients.International journal of molecular sciences · 2021Article
- Diagnostic blood RNA profiles for human acute spinal cord injury.The Journal of experimental medicine · 2021Article
- Why Does COVID-19 Affect Patients with Spinal Cord Injury Milder? A Case-Control Study: Results from Two Observational Cohorts.Journal of personalized medicine · 2020Article
- The Value of MicroRNAs as an Indicator of the Severity and the Acute Phase of Spinal Cord Injury.Annals of rehabilitation medicine · 2019Article
- Biomarkers in Spinal Cord Injury: Prognostic Insights and Future Potentials.Frontiers in neurology · 2019Review
- Evidence for a Role of Nerve Injury in Painful Intervertebral Disc Degeneration: A Cross-Sectional Proteomic Analysis of Human Cerebrospinal Fluid.The journal of pain · 2017Article
- Characterization of the Antibody Response after Cervical Spinal Cord Injury.Journal of neurotrauma · 2017Article
- The Next Generation of Biomarker Research in Spinal Cord Injury.Molecular neurobiology · 2017Review
- The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood.Spinal cord · 2017Review
- Increased expression of ApoA1 after neuronal injury may be beneficial for healing.Molecular and cellular biochemistry · 2017Article
- Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury.Molecular & cellular proteomics : MCP · 2016Review
- Clinical proteomics of enervated neurons.Clinical proteomics · 2016Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recovery of sensory and motor functions following traumatic spinal cord injury (SCI) is dependent on injury severity. Here we identified 49 proteins from cerebrospinal fluid (CSF) of SCI patients, eight of which were differentially abundant among two severity groups of SCI. It was observed that the abundance profiles of these proteins change over a time period of days to months post SCI. Statistical analysis revealed that these proteins take part in several molecular pathways including DNA repair, protein phosphorylation, tRNA transcription, iron transport, mRNA metabolism, immune response and lipid and ATP catabolism. These pathways reflect a set of mechanisms that the system may adopt to cope up with the assault depending on the injury severity, thus leading to observed physiological responses. Apart from putting forward a picture of the molecular scenario at the injury site in a human study, this finding further delineates consequent pathways and molecules that may be altered by external intervention to restrict neural degeneration.
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