Evidence map›Paper›PMID 25350695›Full record

SynthesisNature communications2014

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Iris Postmus, Stella Trompet, Harshal A Deshmukh, Michael R Barnes, Xiaohui Li, Helen R Warren, Daniel I Chasman, Kaixin Zhou, Benoit J Arsenault, Louise A Donnelly and 94 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02783469 (Genetics of Diabetes Audit and Research in Tayside Scotland), which is not on this map. Cited by 137 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02783469 completednot on this map

Genetics of Diabetes Audit and Research in Tayside Scotland (DOLORisk Dundee)

TypeobservationalSponsorUniversity of DundeeRan2004 to 2009Enrolled1,915ConditionsDiabetic Neuropathic PainArmsIdentification of genetic causes of diabetic neuropathic pain
3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Polygenic Prediction of Nongoal Response to Statin Therapy.Circulation. Genomic and precision medicine · 2026
    Article
  14. Polygenic risk scores in pharmacogenomics: methodological challenges, current applications, and perspectives for clinical implementation.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
    Article
  15. Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  16. Article
  17. Article
  18. Article
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  20. Impact ofBiomedicines · 2026
    Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

104 authors.

Iris Postmus1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands.
Stella Trompet1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Harshal A DeshmukhMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Michael R Barnes1] Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK [2] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
Xiaohui LiInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Helen R Warren1] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK [2] Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK.
Daniel I Chasman1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215-1204, USA [2] Harvard Medical School, Boston, Massachusetts 02215, USA.
Kaixin ZhouMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Benoit J ArsenaultMontreal Heart Institute, Universite de Montreal, Montreal H1T 1C8, Quebec, Canada.
Louise A DonnellyMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA.
Christy L AveryDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Paula GriffinDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02215, USA.
QiPing FengDepartment of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37240, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Guo LiCardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
Albert V Smith1] Icelandic Heart Association, IS-201 Kopavogur, Iceland [2] University of Iceland, IS-101 Reykjavik, Iceland.
Catherine E de Keyser1] Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands [2] Health Care Inspectorate, 2595 AN The Hague, The Netherlands.
Andrew D JohnsonFramingham Heart Study (FHS) of the National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics, Framingham, Massachusetts 01702, USA.
Anton J M de Craen1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands.
David J StottFaculty of Medicine, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G31 2ER, UK.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Cork 30, Ireland.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK.
Rudi G J Westendorp1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands [3] Leyden Academy of Vitality and Ageing, 2333 AA Leiden, The Netherlands.
P Eline Slagboom1] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands [2] Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Naveed SattarFaculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow G12 8QQ, UK.
Patricia B Munroe1] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK [2] Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK.
Peter SeverInternational Centre for Circulatory Health, Imperial College, London SW7 2AZ, UK.
Neil PoulterInternational Centre for Circulatory Health, Imperial College, London SW7 2AZ, UK.
Alice Stanton1] Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland [2] Beaumont Hospital, Dublin 9, Ireland.
Denis C Shields1] The Conway Institute, University College Dublin, Dublin 4, Ireland [2] School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland.
Eoin O'BrienThe Conway Institute, University College Dublin, Dublin 4, Ireland.
Sue Shaw-Hawkins1] Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK [2] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
Y-D Ida ChenInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, Washington 98101, USA.
Joshua D SmithDepartment of Genome Sciences, University of Washington, Seattle, Washington 98101, USA.
Marie Pierre DubéMontreal Heart Institute, Universite de Montreal, Montreal H1T 1C8, Quebec, Canada.
S Matthijs BoekholdtDepartment of Cardiology, Academic Medical Center, 1100 DD Amsterdam, The Netherlands.
G Kees HovinghDepartment of Vascular Medicine, Academic Medical Center, 1100 DD Amsterdam, The Netherlands.
John J P KasteleinDepartment of Vascular Medicine, Academic Medical Center, 1100 DD Amsterdam, The Netherlands.
Paul M McKeigueUniversity of Edinburgh, Edinburgh EH9 3JR, UK.
John Betteridge
Andrew NeilUniversity of Oxford, Oxford OX1 2JD, UK.
Paul N DurringtonCardiovascular Research Group, School of Biosciences, University of Manchester, Manchester M13 9NT, UK.
Alex DoneyMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Fiona CarrMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Andrew MorrisMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Mark I McCarthy1] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK [3] Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
Leif GroopDepartment of Clinical Sciences/Diabetes &Endocrinology, Lund University, Malmo 205 02, Sweden.
Emma AhlqvistDepartment of Clinical Sciences/Diabetes &Endocrinology, Lund University, Malmo 205 02, Sweden.
Welcome Trust Case Control Consortium
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, 98115 Seattle, Washington, USA.
Nicholas L Smith1] Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA [2] Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA [3] Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, Washington 98101, USA.
Thomas Lumley1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA [2] Department of Statistic, University of Auckland, Auckland 1142, New Zealand.
Eric A Whitsel1] Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA [2] Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Til StürmerDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Julius S NgwaDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02215, USA.
Christopher J O'Donnell1] NHLBI Framingham Heart Study, Framingham, Massachusetts 01701, USA [2] Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [3] National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA.
Ramachandran S VasanSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, and the Framingham Heart Study, Framingham, Massachusetts 01701, USA.
Wei-Qi WeiDepartment of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee 37240, USA.
Russell A WilkeDepartment of Internal Medicine, Center for IMAGENETICS, Sanford Healthcare, Fargo, North Dakota, 58104 USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02215, USA.
Fangui SunDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02215, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Susan R Heckbert1] Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA [2] Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA [3] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.
Wendy PostDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Nona Sotoodehnia1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA [2] Division of Cardiology, Harborview Medical Center, University of Washington, Seattle 98101, Washington, USA.
Alice M ArnoldDepartment of Biostatistics, University of Washington, 98115 Seattle, Washington, USA.
Jeanette M StaffordDivision of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Jingzhong DingDivision of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
David M HerringtonDepartment of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Stephen B KritchevskyDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Gudny EiriksdottirIcelandic Heart Association, IS-201 Kopavogur, Iceland.
Leonore J LaunerLaboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, Maryland 20892, USA.
Tamara B HarrisLaboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, Maryland 20892, USA.
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215-1204, USA.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215-1204, USA.
Jean G MacFadyenDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215-1204, USA.
Bryan J BarrattPersonalised Healthcare and Biomarkers, AstraZeneca, Alderley Park SK10 4TG, UK.
Fredrik Nyberg1] AstraZeneca Research and Development, 481 83 Mölndal, Sweden [2] Unit of Occupational and Environmental Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
Bruno H Stricker1] Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands [2] Health Care Inspectorate, 2595 AN The Hague, The Netherlands [3] Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
André G Uitterlinden1] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands [2] Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands [3] Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Albert Hofman1] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands [2] Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Valur EmilssonIcelandic Heart Association, IS-201 Kopavogur, Iceland.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215-1204, USA.
Vilmundur Gudnason1] Icelandic Heart Association, IS-201 Kopavogur, Iceland [2] University of Iceland, IS-101 Reykjavik, Iceland.
Yongmei LiuDivision of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Joshua C Denny1] Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee 37240, USA [2] Department of Medicine, Vanderbilt University, Vanderbilt, Tennessee 37240, USA.
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
L Adrienne Cupples1] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02215, USA [2] NHLBI Framingham Heart Study, Framingham, Massachusetts 01701, USA.
Bruce M Psaty1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA [2] Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA [3] Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA [4] Department of Health Services, University of Washington, Seattle, Washington 98101, USA.
Colin N A PalmerMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Jean-Claude TardifMontreal Heart Institute, Universite de Montreal, Montreal H1T 1C8, Quebec, Canada.
Helen M Colhoun1] Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK [2] Department of Public Health, University of Dundee, Dundee DD1 9SY, UK.
Graham HitmanBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Ronald M KraussChildren's Hospital Oakland Research Institute, Oakland, California 94609, USA.
J Wouter Jukema1] Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] Durrer Center for Cardiogenetic Research, 1105 AZ Amsterdam, The Netherlands [3] Interuniversity Cardiology Institute of the Netherlands, 3511 GC Utrecht, The Netherlands.
Mark J Caulfield1] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK [2] Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK.

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Pharmacogenomics and Risk of Cardiovascular DiseaseU19HL069757 · NHLBI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI KRAUSS, RONALD M · 2010 to 2014
$12.8M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
British Heart Foundation PG/13/66/30442Department of HealthIntramural NIH HHSMedical Research Council G0400126Medical Research Council G952010Medical Research Council G9521010Medical Research Council MR/K006584/1NCATS NIH HHS 2 UL1 TR000445NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR000445NCRR NIH HHS RR-024156NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004603NHGRI NIH HHS U01-HG04603NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL068986NHLBI NIH HHS HL073410NHLBI NIH HHS HL080295NHLBI NIH HHS HL085251NHLBI NIH HHS HL087652NHLBI NIH HHS HL103612NHLBI NIH HHS HL105756NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N01 HC-95159NHLBI NIH HHS N01 HC-95160NHLBI NIH HHS N01 HC-95161NHLBI NIH HHS N01 HC-95162NHLBI NIH HHS N01 HC-95163NHLBI NIH HHS N01 HC-95164NHLBI NIH HHS N01 HC-95165NHLBI NIH HHS N01 HC-95166NHLBI NIH HHS N01 HC-95167NHLBI NIH HHS N01 HC-95168NHLBI NIH HHS N01 HC-95169NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL068986NHLBI NIH HHS R01 HL073410NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL59367NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U19 HL069757NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG023629NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01-AG-1-2100NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG023629NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491NIGMS NIH HHS RC2-GM092318PHS HHS HHSN268200625226CWellcome TrustWellcome Trust 084727/Z/08/ZWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/Z
6 · The paper itself

Abstract

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.

Indexed as

Genome-Wide Association StudyCholesterol, LDLHumansHydroxymethylglutaryl-CoA Reductase InhibitorsPharmacogeneticsPolymorphism, Single NucleotideCholesterol, LDLHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID25350695
PMCPMC4220464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.