ArticleJournal of visualized experiments : JoVE2014
Optogenetic stimulation of the auditory nerve.
Article in Journal of visualized experiments : JoVE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Improved optogenetic modification of spiral ganglion neurons for future optical cochlear implants.Theranostics · 2025Article
- Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users.Frontiers in neuroscience · 2023Article
- Channel Interaction During Infrared Light Stimulation in the Cochlea.Lasers in surgery and medicine · 2021Article
- Cochlear implants and other inner ear prostheses: today and tomorrow.Current opinion in physiology · 2020Article
- First biocompatibility margins for optical stimulation at the eardrum via 532-nm laser pulses in a mouse model.Journal of biomedical optics · 2019Article
- Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation.Scientific reports · 2019Article
- Outlook and future of inner ear therapy.Hearing research · 2018Review
- High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics.Nature communications · 2018Article
- Optogenetics for neurodegenerative diseases.International journal of physiology, pathophysiology and pharmacology · 2016Review
- Temporal properties of inferior colliculus neurons to photonic stimulation in the cochlea.Physiological reports · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct electrical stimulation of spiral ganglion neurons (SGNs) by cochlear implants (CIs) enables open speech comprehension in the majority of implanted deaf subjects(1-) (6). Nonetheless, sound coding with current CIs has poor frequency and intensity resolution due to broad current spread from each electrode contact activating a large number of SGNs along the tonotopic axis of the cochlea(7-) (9). Optical stimulation is proposed as an alternative to electrical stimulation that promises spatially more confined activation of SGNs and, hence, higher frequency resolution of coding. In recent years, direct infrared illumination of the cochlea has been used to evoke responses in the auditory nerve(10). Nevertheless it requires higher energies than electrical stimulation(10,11) and uncertainty remains as to the underlying mechanism(12). Here we describe a method based on optogenetics to stimulate SGNs with low intensity blue light, using transgenic mice with neuronal expression of channelrhodopsin 2 (ChR2)(13) or virus-mediated expression of the ChR2-variant CatCh(14). We used micro-light emitting diodes (µLEDs) and fiber-coupled lasers to stimulate ChR2-expressing SGNs through a small artificial opening (cochleostomy) or the round window. We assayed the responses by scalp recordings of light-evoked potentials (optogenetic auditory brainstem response: oABR) or by microelectrode recordings from the auditory pathway and compared them with acoustic and electrical stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.