ArticleJournal of visualized experiments : JoVE2014
Mouse kidney transplantation: models of allograft rejection.
Article in Journal of visualized experiments : JoVE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Intraluminal micro-stenting improves urinary tract reconstruction in murine kidney transplant model.Laboratory animal research · 2026Article
- IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2Nature communications · 2026Article
- The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell-mediated transplant rejection.Science translational medicine · 2025Article
- Senescence-induced p21Cell discovery · 2025Article
- Assessment of Corneal Graft Outcomes in a Murine Model of Endothelial Keratoplasty.Journal of clinical medicine · 2024Article
- Helper T Cell (CD4Research (Washington, D.C.) · 2022Article
- Lymphatic Reconstruction in Kidney Allograft Aggravates Chronic Rejection by Promoting Alloantigen Presentation.Frontiers in immunology · 2021Article
- Single-Cell RNA Sequencing Reveals the Immunological Profiles of Renal Allograft Rejection in Mice.Frontiers in immunology · 2021Article
- Kidney-induced systemic tolerance of heart allografts in mice.JCI insight · 2020Article
- Mitochondria-related reversal of early-stage diabetic nephropathy in donor kidney after transplantation in mice.Annals of translational medicine · 2019Article
- A mouse model of renal ischemia-reperfusion injury solely induced by cold ischemia.American journal of physiology. Renal physiology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Rejection of the transplanted kidney in humans is still a major cause of morbidity and mortality. The mouse model of renal transplantation closely replicates both the technical and pathological processes that occur in human renal transplantation. Although mouse models of allogeneic rejection in organs other than the kidney exist, and are more technically feasible, there is evidence that different organs elicit disparate rejection modes and dynamics, for instance the time course of rejection in cardiac and renal allograft differs significantly in certain strain combinations. This model is an attractive tool for many reasons despite its technical challenges. As inbred mouse strain haplotypes are well characterized it is possible to choose donor and recipient combinations to model acute allograft rejection by transplanting across MHC class I and II loci. Conversely by transplanting between strains with similar haplotypes a chronic process can be elicited were the allograft kidney develops interstitial fibrosis and tubular atrophy. We have modified the surgical technique to reduce operating time and improve ease of surgery, however a learning curve still needs to be overcome in order to faithfully replicate the model. This study will provide key points in the surgical procedure and aid the process of establishing this technique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.