ArticleJournal of visualized experiments : JoVE2014
Non-terminal blood sampling techniques in guinea pigs.
Article in Journal of visualized experiments : JoVE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effects of exposure to Rickettsia bellii on reservoir competence of guinea pigs for Rickettsia rickettsiiMemorias do Instituto Oswaldo Cruz · 2026Article
- Biological Variation in Biochemistry Analytes in Laboratory Guinea Pigs (Veterinary sciences · 2023Article
- Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in Guinea Pigs with Non-Alcoholic Steatohepatitis.Nutrients · 2023Article
- Evaluating the Clinical and Immune Responses to Spotted Fever Rickettsioses in the Guinea Pig-Tick-Rickettsia System.Current protocols · 2022Article
- Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig.Antioxidants (Basel, Switzerland) · 2021Article
- Differential Effects of Dietary Components on Glucose Intolerance and Non-Alcoholic Steatohepatitis.Nutrients · 2021Article
- Evaluation of the designed multi-epitope protein ofIranian journal of basic medical sciences · 2021Article
- Beyond the IFA: Revisiting the ELISA as a More Sensitive, Objective, and Quantitative Evaluation of Spotted Fever GroupPathogens (Basel, Switzerland) · 2021Article
- The guinea pig model for tick-borne spotted fever rickettsioses: A second look.Ticks and tick-borne diseases · 2020Review
- Hematologic Parameters and Blood Cultures from the Gingival Vein Compared with the Cranial Vena Cava in Guinea Pigs.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Bone Marrow and Peripheral Blood Cells Toxicity of a Single 2.0 Gy CobaltEthiopian journal of health sciences · 2019Article
- Pharmacokinetics and Adverse Effects of 3 Sustained-release Buprenorphine Dosages in Healthy Guinea Pigs (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters.PloS one · 2017Article
- The gingival vein as a minimally traumatic site for multiple blood sampling in guinea pigs and hamsters.PloS one · 2017Article
- L-dehydroascorbic acid can substitute l-ascorbic acid as dietary vitamin C source in guinea pigs.Redox biology · 2016Article
- High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs.Nutrition & metabolism · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guinea pigs possess several biological similarities to humans and are validated experimental animal models(1-3). However, the use of guinea pigs currently represents a relatively narrow area of research and descriptive data on specific methodology is correspondingly scarce. The anatomical features of guinea pigs are slightly different from other rodent models, hence modulation of sampling techniques to accommodate for species-specific differences, e.g., compared to mice and rats, are necessary to obtain sufficient and high quality samples. As both long and short term in vivo studies often require repeated blood sampling the choice of technique should be well considered in order to reduce stress and discomfort in the animals but also to ensure survival as well as compliance with requirements of sample size and accessibility. Venous blood samples can be obtained at a number of sites in guinea pigs e.g., the saphenous and jugular veins, each technique containing both advantages and disadvantages(4,5). Here, we present four different blood sampling techniques for either conscious or anaesthetized guinea pigs. The procedures are all non-terminal procedures provided that sample volumes and number of samples do not exceed guidelines for blood collection in laboratory animals(6). All the described methods have been thoroughly tested and applied for repeated in vivo blood sampling in studies within our research facility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.