Evidence map›Paper›PMID 25350377›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2015

Equine model for soft-tissue regeneration.

E Bellas, A Rollins, J E Moreau, T Lo, K P Quinn, N Fourligas, I Georgakoudi, G G Leisk, M Mazan, K E Thane and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

E Bellas *Department of Biomedical Engineering, Tufts University, Medford, MA.
A Rollins *Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
J E MoreauDepartment of Biomedical Engineering, Tufts University, Medford, MA.
T LoDepartment of Mechanical Engineering, Tufts University, Medford, MA.
K P QuinnDepartment of Biomedical Engineering, Tufts University, Medford, MA.
N FourligasDepartment of Biomedical Engineering, Tufts University, Medford, MA.
I GeorgakoudiDepartment of Biomedical Engineering, Tufts University, Medford, MA.
G G LeiskDepartment of Mechanical Engineering, Tufts University, Medford, MA.
M MazanCummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
K E ThaneCummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
O TaeymansCummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
A M HoffmanCummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
D L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA.
C A Kirker-HeadCummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
Tufts University · USZero to Three · US

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Translational Research in Regenerative MedicineT32EB005583 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM, PAREKKADAN, BIJU · 2006 to 2022
$4.7M
Optical monitoring of engineered tissuesR01EB007542 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI GEORGAKOUDI, IRENE · 2009 to 2012
$1.3M
Non-invasive optical biomarkers to quantify engineered bone tissue developmentF32AR061933 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI QUINN, KYLE PATRICK · 2011 to 2012
$96k
NIAMS NIH HHS F32 AR061933NIAMS NIH HHS F32AR061933NIBIB NIH HHS P41 EB002520NIBIB NIH HHS R01 EB007542NIBIB NIH HHS R01EB007542NIBIB NIH HHS T32 EB005583
6 · The paper itself

Abstract

Soft-tissue regeneration methods currently yield suboptimal clinical outcomes due to loss of tissue volume and a lack of functional tissue regeneration. Grafted tissues and natural biomaterials often degrade or resorb too quickly, while most synthetic materials do not degrade. In previous research we demonstrated that soft-tissue regeneration can be supported using silk porous biomaterials for at least 18 months in vivo in a rodent model. In the present study, we scaled the system to a survival study using a large animal model and demonstrated the feasibility of these biomaterials for soft-tissue regeneration in adult horses. Both slow and rapidly degrading silk matrices were evaluated in subcutaneous pocket and intramuscular defect depots. We showed that we can effectively employ an equine model over 6 months to simultaneously evaluate many different implants, reducing the number of animals needed. Furthermore, we were able to tailor matrix degradation by varying the initial format of the implanted silk. Finally, we demonstrate ultrasound imaging of implants to be an effective means for tracking tissue regeneration and implant degradation.

Indexed as

Absorbable ImplantsDisease Models, AnimalRegenerationAnimalsHorsesMuscle, SkeletalSilkUltrasonographySilkanimal modelin vivo testmesenchymal stem cellscaffoldsilk

Identifiers

PMID25350377
PMCPMC4868549
OpenAlexW2159411591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.