ArticleTranslational psychiatry2014
Investigation of blood mRNA biomarkers for suicidality in an independent sample.
Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- Peripheral NORAD lncRNA and MARCKS mRNA expression in suicidal adolescents: a case-control studyMolecular biology reports · 2025Article
- The Impact ofInternational journal of molecular sciences · 2023Article
- Depression and suicide risk prediction models using blood-derived multi-omics data.Translational psychiatry · 2019Article
- Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder.Frontiers in genetics · 2019Article
- Gene expression associated with suicide attempts in US veterans.Translational psychiatry · 2017Article
- The promise of biomarkers in diagnosing major depression in primary care: the present and future.Current psychiatry reports · 2015Review
- Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions.Molecular psychiatry · 2015Article
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 8 countries.
Funding
Abstract
Changes in the blood expression levels of SAT1, PTEN, MAP3K3 and MARCKS genes have been reported as biomarkers of high versus low suicidality state (Le-Niculescu et al.). Here, we investigate these expression biomarkers in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study, of patients with major depressive disorder on a 12-week antidepressant treatment. Blood gene expression levels were available at baseline and week 8 for patients who experienced suicidal ideation during the study (n=20) versus those who did not (n=37). The analysis is well powered to detect the effect sizes reported in the original paper. Within either group, there was no significant change in the expression of these four genes over the course of the study, despite increasing suicidal ideation or initiation of antidepressant treatment. Comparison of the groups showed that the gene expression did not differ between patients with or without treatment-related suicidality. This independent study does not support the validity of the proposed biomarkers.
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Registered trials
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