ReviewNature neuroscience2014
Analytical tools and current challenges in the modern era of neuroepigenomics.
Review in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies.Molecular psychiatry · 2023Pooled it
- Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus.BMC genomics · 2024Article
- Neuroepigenetic Editing.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Failure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice.Human molecular genetics · 2023Article
- Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum.Nature communications · 2022Article
- Epigenetic Mechanisms in Drug Relapse.Biological psychiatry · 2021Review
- Cell Type-Specific Oxidative Stress Genomic Signatures in the Globus Pallidus of Dopamine-Depleted Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Early-life adversity and neurological disease: age-old questions and novel answers.Nature reviews. Neurology · 2019Review
- Application of Computational Biology to Decode Brain Transcriptomes.Genomics, proteomics & bioinformatics · 2019Review
- Molecular windows into the human brain for psychiatric disorders.Molecular psychiatry · 2019Review
- Article
- The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms.Neuron · 2019Review
- Epigenetics for the 21st-Century Biology Student.Journal of microbiology & biology education · 2019Article
- Article
- Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks.Journal of affective disorders · 2018Review
- Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo.Journal of visualized experiments : JoVE · 2018Article
- Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease.Scientific reports · 2018Article
- A Clinician's Perspective on Biomarkers.Focus (American Psychiatric Publishing) · 2018Review
- A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.Nature communications · 2018Article
- Epigenetic mechanisms underlying nervous system diseases.Handbook of clinical neurology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Over the past decade, rapid advances in epigenomics research have extensively characterized critical roles for chromatin regulatory events during normal periods of eukaryotic cell development and plasticity, as well as part of aberrant processes implicated in human disease. Application of such approaches to studies of the CNS, however, is more recent. Here we provide a comprehensive overview of available tools for analyzing neuroepigenomics data, as well as a discussion of pending challenges specific to the field of neuroscience. Integration of numerous unbiased genome-wide and proteomic approaches will be necessary to fully understand the neuroepigenome and the extraordinarily complex nature of the human brain. This will be critical to the development of future diagnostic and therapeutic strategies aimed at alleviating the vast array of heterogeneous and genetically distinct disorders of the CNS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.