ReviewNature neuroscience2014
Decoding neural transcriptomes and epigenomes via high-throughput sequencing.
Review in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Dynamics of Neurogenic Signals as Biological Switchers of Brain Plasticity.Stem cell reviews and reports · 2024Review
- N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats.Cell death & disease · 2023Article
- Advancements in Genomic and Behavioral Neuroscience Analysis for the Study of Normal and Pathological Brain Function.Frontiers in molecular neuroscience · 2022Review
- Recent advances in tissue stem cells.Science China. Life sciences · 2021Review
- Cortical cellular diversity and development in schizophrenia.Molecular psychiatry · 2021Review
- Application of Computational Biology to Decode Brain Transcriptomes.Genomics, proteomics & bioinformatics · 2019Review
- H3K36 Methylation in Neural Development and Associated Diseases.Frontiers in genetics · 2019Review
- Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence.The Journal of cell biology · 2018Review
- Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn.Scientific reports · 2018Article
- A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.Nature communications · 2018Article
- Retrieval-Induced Upregulation of Tet3 in Pyramidal Neurons of the Dorsal Hippocampus Mediates Cocaine-Associated Memory Reconsolidation.The international journal of neuropsychopharmacology · 2018Article
- Radial glial cells in the adult dentate gyrus: what are they and where do they come from?F1000Research · 2018Review
- Brain transcriptome atlases: a computational perspective.Brain structure & function · 2017Review
- Article
- Opening up the DNA methylome of dementia.Molecular psychiatry · 2017Review
- Neuronal activity modifies the chromatin accessibility landscape in the adult brain.Nature neuroscience · 2017Article
- Contribution of Neuroepigenetics to Huntington's Disease.Frontiers in human neuroscience · 2017Review
- Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities.Cell stem cell · 2016Review
- The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Epigenetic mechanisms in neurogenesis.Nature reviews. Neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The mammalian brain is an evolutionary marvel in which engraving and re-engraving of cellular states enable complex information processing and lifelong maintenance. Understanding the mechanisms by which neurons alter and maintain their molecular signatures during information processing is a fundamental goal of neuroscience. Next-generation sequencing (NGS) technology is rapidly transforming the ability to probe the molecular basis of neuronal function. NGS can define not only the complete molecular signatures of cells by transcriptome analyses but also the cascade of events that induce or maintain such signatures by epigenetic analyses. Here we offer some general and practical information to demystify NGS technology and highlight its potential to the neuroscience field. We start with discussion of the complexity of the nervous system, then introduce various applications of NGS with practical considerations and describe basic principles underlying various NGS technologies. Finally, we discuss emerging NGS-related technologies for the neuroscience field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.