Evidence map›Paper›PMID 25349778›Full record

ArticleFEBS open bio2014

Is there a link between proprotein convertase PC7 activity and human lipid homeostasis?

Johann Guillemot, Rachid Essalmani, Josée Hamelin, Nabil G Seidah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  5. The motif EThe Journal of biological chemistry · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Johann GuillemotLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Affiliated to the University of Montreal, 110 Pine Ave West, Montreal, Quebec H2W 1R7, Canada.
Rachid EssalmaniLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Affiliated to the University of Montreal, 110 Pine Ave West, Montreal, Quebec H2W 1R7, Canada.
Josée HamelinLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Affiliated to the University of Montreal, 110 Pine Ave West, Montreal, Quebec H2W 1R7, Canada.
Nabil G SeidahLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Affiliated to the University of Montreal, 110 Pine Ave West, Montreal, Quebec H2W 1R7, Canada.
Montreal Clinical Research Institute · CAUniversité de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A genome-wide association study suggested that a R504H mutation in the proprotein convertase PC7 is associated with increased circulating levels of HDL and reduced triglycerides in black Africans. Our present results show that PC7 and PC7-R504H exhibit similar processing of transferrin receptor-1, proSortilin, and apolipoprotein-F. Plasma analyses revealed no change in the lipid profiles, insulin or glucose of wild type and PC7 KO mice. Thus, the R504H mutation does not modify the proteolytic activity of PC7. The mechanisms behind the implication of PC7 in the regulation of human HDL, triglycerides and in modifying the levels of atherogenic small dense LDL remain to be elucidated.

Indexed as

ANGPTL3, angiopoietin-like 3ANGPTL4, angiopoietin-like 4ApoF, apolipoprotein-FApolipoprotein FGOF, gain of functionGWAS, genome-wide association studyHDL, high-density lipoproteinHDL/LDLhTfR1, human PC7-substrates: transferrin receptor 1KO, knockoutLDL, low-density lipoproteinPCs, proprotein convertasesProprotein convertase PC7SNP, single nucleotide polymorphismSortilinTGN, trans Golgi networkTMD, transmembrane domainTransferrin receptor 1TriglyceridesVLDL, very low-density lipoprotein

Identifiers

PMID25349778
PMCPMC4208093
OpenAlexW2030432059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.