Evidence map›Paper›PMID 25349683›Full record

ArticleMiddle East journal of digestive diseases2014

Target antigens for perinuclear antineutrophil cytoplasmic antibodies in Iranian patients with ulcerative colitis.

Ali Bahari, Mahmoud Aarabi, Mehdi Hedayati, Ali Jarollahi, Farzad Firouzi, Rahim Aghazadeh, Mohammad Reza Zali, Zohreh Bari, Mohammad Hashemi, Abbas Esmaeilzadeh and 2 more

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In one paragraph

Article in Middle East journal of digestive diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ali BahariEndoscopic & Minimally Invasive Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahmoud AarabiDepartment of Inflammatory Bowel Disease, Research Center of Gastroenterology and Liver Diseases, Tehran, Iran ; Department of Biomedical & Molecular Sciences, Queen's University, Canada.
Mehdi HedayatiClinical Laboratory, Research Center for Endocrinology and Metabolic Diseases, Tehran, Iran.
Ali JarollahiClinical Pathology Laboratory, Mofid Children Hospital, Tehran, Iran.
Farzad FirouziResearch Institute of Gastroenterology and Liver Diseases (RIGLD), Shahid Beheshti University, Tehran, Iran.
Rahim AghazadehDepartment of Inflammatory Bowel Disease, Research Center of Gastroenterology and Liver Diseases, Tehran, Iran.
Mohammad Reza ZaliDepartment of Inflammatory Bowel Disease, Research Center of Gastroenterology and Liver Diseases, Tehran, Iran.
Zohreh BariDepartment of Gastroenterology, Mazandaran University of Medical Sciences, Sari, Iran.
Mohammad HashemiDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran ; Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Abbas EsmaeilzadehDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Ali MokhtarifarDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Azita GanjiDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences · IRMazandaran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledBACKGROUND Patients with ulcerative colitis (UC) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-ANCA).

objectiveThe aim of the present study was to evaluate the target antigens for p-ANCA in Iranian patients with UC. METHODS p-ANCA target antigens including elastase, lactoferrin, cathepsin G, myeloproxidase, lysozyme, and bactericidal permeability increasing protein (BPI) were determined in 113 patients with UC using enzyme-linked immunosorbent assay (ELISA). RESULTS 59.2% of the patients were positive for at least one antigen and p-ANCA directed against lactoferrin, elastase, lysozyme, cathepsin G, Bactericidal permeability increasing protein, and myeloproxidase in 31.5%, 25.9%, 8.3%, 7.4%, 5.6%, and 0% of the patients, respectively. CONCLUSION The highest prevalence of p-ANCA was observed against lactoferrin and elastase. Also, myeloproxidase was not an antigen for p-ANCA among our patients.

Indexed as

Anti-neutrophil cytoplasmic antibodyInflammatory bowel diseaseTtarget antigenUlcerative colitis

Identifiers

PMID25349683
PMCPMC4208928
OpenAlexW2111358034

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.