ReviewMiddle East journal of digestive diseases2014
Systematic review of zinc biomarkers and esophageal cancer risk.
Review in Middle East journal of digestive diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Mineral Intake and Cardiovascular Disease, Cancer, and All-Cause Mortality: Findings from the Golestan Cohort Study.Nutrients · 2024Article
- Iron, Copper, and Magnesium Concentration in Hair and Risk of Esophageal Cancer: A Nested Case-Control Study.Archives of Iranian medicine · 2023Article
- Zinc dysregulation in cancers and its potential as a therapeutic target.Cancer biology & medicine · 2020Review
- Turmeric, Pepper, Cinnamon, and Saffron Consumption and Mortality.Journal of the American Heart Association · 2019Article
- Nut and Peanut Butter Consumption and Mortality in the National Institutes of Health-AARP Diet and Health Study.Nutrients · 2019Observational
- The application of six dietary scores to a Middle Eastern population: a comparative analysis of mortality in a prospective study.European journal of epidemiology · 2019Article
- Serum Levels of Zinc, Copper and Ferritin in Patients with Salivary Gland TumorsAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study.British journal of cancer · 2018Article
- Toenail mineral concentration and risk of esophageal squamous cell carcinoma, results from the Golestan Cohort Study.Cancer medicine · 2017Article
- Research progress on the relationship between zinc deficiency, related microRNAs, and esophageal carcinoma.Thoracic cancer · 2017Review
- Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes.The American journal of clinical nutrition · 2017Article
- Nut consumption and total and cause-specific mortality: results from the Golestan Cohort Study.International journal of epidemiology · 2017Article
- Diet and the Gut.Middle East journal of digestive diseases · 2016Article
- The Nail as a Biomonitor of Trace Element Status in Golestan Cohort Study.Middle East journal of digestive diseases · 2016Article
- Systematic review of zinc biochemical indicators and risk of coronary heart disease.ARYA atherosclerosis · 2015Review
- Micronutrients: A Double-Edged Sword in Microbe-Induced Gastric Carcinogenesis.Trends in cancer · 2015Review
- Dietary intake of minerals and risk of esophageal squamous cell carcinoma: results from the Golestan Cohort Study.The American journal of clinical nutrition · 2015Article
- Africa's Oesophageal Cancer Corridor: Geographic Variations in Incidence Correlate with Certain Micronutrient Deficiencies.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND It is hypothesized that poor zinc nutritional status is associated with an increased risk of esophageal cancer (EC), but current evidence is contradictory. Since some factors may influence zinc absorption, its status may be better evaluated thorough biomarkers. The objectives of this study were to perform a systematic review on the association of zinc biomarkers with EC in observational studies and to evaluate the efficacy of zinc supplements in preventing EC in randomized trials. METHODS The MEDLINE database was searched in December 2013 for studies written in English with relevant keywords. Articles which met inclusion criteria were included in this study. RESULTS Eleven observational studies that measured zinc biomarkers and eight randomized trials which evaluated supplements containing zinc, met our inclusion criteria. The majority of studies suggested that higher zinc status was inversely associated with EC risk. CONCLUSION Most of the evidence for this hypothesis comes from case-control studies, which may introduce bias. Cohort studies are needed to establish whether poor zinc status is associated with increased risk for EC. Findings from trials are inconclusive as there is no data from single agent trials. However, the evidence is not still strong enough to conclude a protective role of zinc in EC.
Indexed as
Identifiers
25349680PMC4208925W2156537654What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.