ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
The molecular underpinnings of totipotency.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Article
- Reprogramming of fibroblast cells to totipotent state by DNA demethylation.Scientific reports · 2023Article
- Article
- Prenatal and postnatal MRI imaging findings of intracranial parasitic fetus: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- A plug and play microfluidic platform for standardized sensitive low-input chromatin immunoprecipitation.Genome research · 2021Article
- Developmental Plasticity and Cellular Reprogramming inGenetics · 2019Review
- On Mammalian Totipotency: What Is the Molecular Underpinning for the Totipotency of Zygote?Stem cells and development · 2019Review
- Plausibility of trophoblastic-like regulation of cancer tissue.Cancer management and research · 2019Article
- Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells.Nature communications · 2017Article
- Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons.Nature genetics · 2017Article
- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- Membrane translocation of t-SNARE protein syntaxin-4 abrogates ground-state pluripotency in mouse embryonic stem cells.Scientific reports · 2017Article
- Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals.BMC biology · 2016Article
- Regenerative Perspective in Modern Dentistry.Dentistry journal · 2016Review
- Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic stem (ES) cells are characterized by their functional potency and capacity to self-renew in culture. Historically, ES cells have been defined as pluripotent, able to make the embryonic but not the extraembryonic lineages (such as the yolk sac and the placenta). The functional capacity of ES cells has been judged based on their ability to contribute to all somatic lineages when they are introduced into an embryo. However, a number of recent reports have suggested that under certain conditions, ES cells, and other reprogrammed cell lines, can also contribute to the extraembryonic lineages and, therefore, can be said to be totipotent. Here, we consider the molecular basis for this totipotent state, its transcriptional signature and the signalling pathways that define it.
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