Evidence map›Paper›PMID 25349455›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014

Gutsy moves in mice: cellular and molecular dynamics of endoderm morphogenesis.

Manuel Viotti, Ann C Foley, Anna-Katerina Hadjantonakis

Open access · bronzeAbstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Signals and forces shaping organogenesis of the small intestine.Current topics in developmental biology · 2019
    Review
  9. ABiology open · 2018
    Article
  10. Article
  11. Concepts of Cell Lineage in Mammalian Embryos.Current topics in developmental biology · 2016
    Review
  12. Review
  13. Article
  14. Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014
    Review
  15. From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Manuel ViottiGenentech Incorporated, South San Francisco, CA 94080, USA.
Ann C FoleyDepartment of Bioengineering, Clemson University, Charleston, SC 29425, USA.
Anna-Katerina HadjantonakisDevelopmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA hadj@mskcc.org.
Clemson University · USKettering University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Morphogenesis of the paraxial mesoderm in miceR01HD052115 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI HADJANTONAKIS, ANNA-KATERINA · 2006 to 2015
$4.1M
NCI NIH HHS P30 CA008748NICHD NIH HHS R01 HD052115
6 · The paper itself

Abstract

Despite the importance of the gut and its accessory organs, our understanding of early endoderm development is still incomplete. Traditionally, endoderm has been difficult to study because of its small size and relative fragility. However, recent advances in live cell imaging technologies have dramatically expanded our understanding of this tissue, adding a new appreciation for the complex molecular and morphogenetic processes that mediate gut formation. Several spatially and molecularly distinct subpopulations have been shown to exist within the endoderm before the onset of gastrulation. Here, we review findings that have uncovered complex cell movements within the endodermal layer, before and during gastrulation, leading to the conclusion that cells from primitive endoderm contribute descendants directly to gut.

Indexed as

AnimalsCell DifferentiationCell MovementEndodermGastrointestinal TractMiceModels, BiologicalMorphogenesisdefinitive endodermepithelial-to-mesenchymal transitiongastrulationgut morphogenesismesenchymal-to-epithelial transitionvisceral endoderm

Identifiers

PMID25349455
PMCPMC4216469
OpenAlexW2100468762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.