ArticleThe American journal of tropical medicine and hygiene2015
Calcified neurocysticercosis associates with hippocampal atrophy: a population-based study.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Histopathological, immunohistochemical, and molecular characterization of Coenurus cerebralis infection in sheep with evaluation of cerebrospinal cytokine responses.Parasitology research · 2026Article
- A Comprehensive Review of Worldwide Case Series of Neurocysticercosis and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.Neuroimmunomodulation · 2026Review
- Calcified Neurocysticercosis: Understanding Dead (Not Necessarily Inactive) Parasites.The American journal of tropical medicine and hygiene · 2025Review
- The process of residual calcification following antiparasitic treatment in the pig model of neurocysticercosis is dynamic.PLoS neglected tropical diseases · 2025Article
- Temporal trends and future projections of cysticercosis-induced epilepsy: insights from the global burden of disease study 2021- a cross-sectional study.Frontiers in public health · 2025Article
- Large (≥3-Millimeter) Parenchymal Brain Calcified Cysticerci Are More Often Associated with Hippocampal Atrophy than Smaller Ones in Seizure-Free Individuals with a Single Lesion.The American journal of tropical medicine and hygiene · 2024Article
- Calcified Neurocysticercosis: Demographic, Clinical, and Radiological Characteristics of a Large Hospital-Based Patient Cohort.Pathogens (Basel, Switzerland) · 2023Article
- Neurocysticercosis in Low- and Middle-Income Countries, a Diagnostic Challenge from Oyam District, Uganda.Infectious disease reports · 2022Article
- CystiHuman: A model of human neurocysticercosis.PLoS computational biology · 2022Article
- Predictors of Seizure Recurrence in Solitary Calcified Neurocysticercosis in Relation to Computed Tomography Scan: Prospective Observational Study.Journal of epilepsy research · 2021Article
- Frequency and Determinant Factors for Calcification in Neurocysticercosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Hippocampal Atrophy/Sclerosis Is Associated with Old, Calcified Parenchymal Brain Neurocysticercosis, But Not with More Recent, Viable Infections.The American journal of tropical medicine and hygiene · 2021Article
- Incidence of Adult-Onset Epilepsy and the Contributory Role of Neurocysticercosis in a Five-Year, Population-Based, Prospective Study in Rural Ecuador.The American journal of tropical medicine and hygiene · 2021Article
- Changes in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis.PLoS neglected tropical diseases · 2021Article
- Evaluating the Association of Calcified Neurocysticercosis and Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis in a Large Cohort of Patients With Epilepsy.Frontiers in neurology · 2021Article
- Unique Characteristics of Epilepsy Development in Neurocysticercosis.The American journal of tropical medicine and hygiene · 2020Review
- Taenia solium Cysticercosis and Its Impact in Neurological Disease.Clinical microbiology reviews · 2020Review
- Host immune responses during Taenia solium Neurocysticercosis infection and treatment.PLoS neglected tropical diseases · 2020Review
- An Ambispective Cohort Study to Assess Seizure Recurrences in Children with Calcified Parenchymal Neurocysticercosis.The American journal of tropical medicine and hygiene · 2019Article
- Axonal swelling and spheroids in Taenia solium neurocysticercosis.Brain pathology (Zurich, Switzerland) · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Calcified neurocysticercosis has been associated with hippocampal atrophy in patients with refractory epilepsy, but the relevance of this association in the population at large is unknown. We assessed calcified cysticerci and its association with hippocampal atrophy in elderly persons living in Atahualpa, an Ecuadorian village endemic for neurocysticercosis. All Atahualpa residents ≥ 60 years of age were invited to undergo computed tomography/magnetic resonance imaging for neurocysticercosis detection. Twenty-eight (11%) out of 248 enrolled persons had calcified cysticerci (case-patients) and were matched 1:1 by age, sex, and years of education to individuals without neurocysticercosis on computed tomography/magnetic resonance imaging (controls). Four case-patients and none of the controls had epilepsy (P = 0.134). Cognitive performance was similar across both groups. The Scheltens' medial temporal atrophy scale was used for hippocampal rating in case-patients and matched controls without neurocysticercosis. Mean score in the Scheltens' scale was higher in case-patients than in controls (P < 0.001). Atrophic hippocampi were noticed in 19 case-patients and five controls (P = 0.003). Atrophy was bilateral in 11 case-patients and unilateral in eight. All case-patients with unilateral hippocampal atrophy had at least one ipsilateral calcification. This study shows an association between calcified cysticerci and hippocampal atrophy and raises the possibility of an inflammation-mediated hippocampal damage as the responsible mechanism for these findings.
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