Trial reportPediatrics2014
Perinatal complications and aging indicators by midlife.
Trial report in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology.PloS one · 2016Trial
- Long-Term Consequences of Preterm Birth: A Lifespan Perspective.Developmental neuroscience · 2026Review
- The long-term associations of perinatal obesogenic environment with offspring biological aging.American journal of epidemiology · 2025Article
- Perinatal exposures and adolescence overweight: The role of shared maternal-offspring pathways.Atherosclerosis · 2024Article
- Early origins of health and disease risk: The case for investigating adverse exposures and biological aging in utero, across childhood, and into adolescence.Child development perspectives · 2023Article
- Education mediating the associations between early life factors and frailty: a cross-sectional study of the UK Biobank.BMJ open · 2023Article
- Mortality in individuals with childhood ADHD or subthreshold symptoms - a prospective perinatal risk cohort study over 40 years.BMC psychiatry · 2022Article
- Prenatal exposure to maternal psychological distress and telomere length in childhood.Developmental psychobiology · 2022Article
- Adults Born Preterm–Long-Term Health Risks of Former Very Low Birth Weight Infants.Deutsches Arzteblatt international · 2021Article
- Long-term Neural Embedding of Childhood Adversity in a Population-Representative Birth Cohort Followed for 5 Decades.Biological psychiatry · 2021Article
- A Novel Association between YKL-40, a Marker of Structural Lung Disease, and Short Telomere Length in 10-Year-Old Children with Bronchopulmonary Dysplasia.Children (Basel, Switzerland) · 2021Article
- Telomere length: how the length makes a difference.Molecular biology reports · 2020Review
- Cumulative Antenatal Risk and Kindergarten Readiness in Preterm-Born Preschoolers.Journal of abnormal child psychology · 2020Article
- Neonatal hyperoxia exposure induces aortic biomechanical alterations and cardiac dysfunction in juvenile rats.Physiological reports · 2020Article
- Association of facial ageing with DNA methylation and epigenetic age predictions.Clinical epigenetics · 2018Article
- Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?American journal of epidemiology · 2018Article
- The fetal programming of telomere biology hypothesis: an update.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Article
- Telomere Length in Newborns is Related to Maternal Stress During Pregnancy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2017Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundPerinatal complications predict increased risk for morbidity and early mortality. Evidence of perinatal programming of adult mortality raises the question of what mechanisms embed this long-term effect. We tested a hypothesis related to the theory of developmental origins of health and disease: that perinatal complications assessed at birth predict indicators of accelerated aging by midlife.
methodsPerinatal complications, including both maternal and neonatal complications, were assessed in the Dunedin Multidisciplinary Health and Development Study cohort (N = 1037), a 38-year, prospective longitudinal study of a representative birth cohort. Two aging indicators were assessed at age 38 years, objectively by leukocyte telomere length (TL) and subjectively by perceived facial age.
resultsPerinatal complications predicted both leukocyte TL (β = -0.101; 95% confidence interval, -0.169 to -0.033; P = .004) and perceived age (β = 0.097; 95% confidence interval, 0.029 to 0.165; P = .005) by midlife. We repeated analyses with controls for measures of family history and social risk that could predispose to perinatal complications and accelerated aging, and for measures of poor health taken in between birth and the age-38 follow-up. These covariates attenuated, but did not fully explain the associations observed between perinatal complications and aging indicators.
conclusionsOur findings provide support for early-life developmental programming by linking newborns' perinatal complications to accelerated aging at midlife. We observed indications of accelerated aging "inside," as measured by leukocyte TL, an indicator of cellular aging, and "outside," as measured by perceived age, an indicator of declining tissue integrity. A better understanding of mechanisms underlying perinatal programming of adult aging is needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.