Evidence map›Paper›PMID 25349317›Full record

ArticlePediatrics2014

Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants.

John Kelleher, Ariel A Salas, Ramachandra Bhat, Namasivayam Ambalavanan, Shampa Saha, Barbara J Stoll, Edward F Bell, Michele C Walsh, Abbot R Laptook, Pablo J Sánchez and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Observational
  6. Article
  7. Single cell analysisFrontiers in immunology · 2023
    Article
  8. Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Article
  9. Review
  10. Article
  11. Management of neonatal spontaneous intestinal perforation by peritoneal needle aspiration.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Article
  12. Article
  13. Article
  14. Enteral feeding during indomethacin treatment for patent ductus arteriosus: association with gastrointestinal outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 1 country.

John KelleherDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama;
Ariel A SalasDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama;
Ramachandra BhatDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama;
Namasivayam AmbalavananDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama;
Shampa SahaSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina;
Barbara J StollDepartment of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, Georgia;
Edward F BellDepartment of Pediatrics, University of Iowa, Iowa City, Iowa;
Michele C WalshEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland;
Abbot R LaptookDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, Ohio;
Pablo J SánchezDepartment of Pediatrics, Women & Infants' Hospital, Brown University, Providence, Rhode Island;
Seetha ShankaranDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Krisa P VanMeursDepartment of Pediatrics, Wayne State University, Detroit, Michigan;
Ellen C HaleDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama;
Nancy S NewmanEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland;
M Bethany BallDepartment of Pediatrics, Wayne State University, Detroit, Michigan;
Abhik DasDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, California; and.
Rosemary D HigginsSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, Maryland.
Myriam Peralta-CarcelenDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama;
Waldemar A CarloDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama; wcarlo@peds.uab.edu.
GDB Subcommittee, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Research Network (United States) · USUniversity of Alabama at Birmingham · USWayne State University · USNational Institutes of Health · USRTI International · USBrown University · USEmory University · USRainbow Babies & Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Iowa · US

Funding

Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KOCH, KENNETH L · 1992 to 2010
$35.2M
VITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI STRAUSS, ARNOLD W · 1994 to 2009
$20.6M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021385 · NICHD · WAYNE STATE UNIVERSITY · PI SHANKARAN, SEETHA · 1991 to 2015
$8.7M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027904 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LAPTOOK, ABBOT R · 1991 to 2015
$8.7M
USE OF OXANDROLONE TO IMPROVE FUNCTION IN CHRONIC SCIM01RR016587 · NCRR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALEJANDRO, RODOLFO · 2002 to 2005
$6.8M
ZIPRASIDONE TREATMENT OF TOURETTE'S SYNDROME IN CHILDRENM01RR006022 · NCRR · YALE UNIVERSITY · PI KESSLER, DAVID A · 1990 to 2003
$6.7M
MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITSU10HD021397 · NICHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DUARA, SHAHNAZ · 1991 to 2006
$6.7M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD034216 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 1996 to 2015
$6.4M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027853 · NICHD · UNIVERSITY OF CINCINNATI · PI SCHIBLER, KURT R · 1991 to 2015
$6.2M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027880 · NICHD · STANFORD UNIVERSITY · PI VAN MEURS, KRISA PAGE · 1991 to 2015
$6.1M
NCRR NIH HHS M01 RR006022NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR008084NCRR NIH HHS M01 RR016587NCRR NIH HHS M01 RR125NCRR NIH HHS M01 RR16587NCRR NIH HHS M01 RR30NCRR NIH HHS M01RR32NCRR NIH HHS M01 RR39NCRR NIH HHS M01 RR44NCRR NIH HHS M01 RR54NCRR NIH HHS M01RR59NCRR NIH HHS M01 RR6022NCRR NIH HHS M01 RR633NCRR NIH HHS M01 RR64NCRR NIH HHS M01 RR70NCRR NIH HHS M01 RR7122NCRR NIH HHS M01 RR750NCRR NIH HHS M01 RR80NCRR NIH HHS M01 RR8084NCRR NIH HHS M01 RR997NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1 RR24139NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040498NICHD NIH HHS U10 HD040521NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053089NICHD NIH HHS U10 HD053109NICHD NIH HHS U10 HD053119NICHD NIH HHS U10 HD053124NICHD NIH HHS U10 HD21364NICHD NIH HHS U10 HD21373NICHD NIH HHS U10 HD21385NICHD NIH HHS U10 HD21397NICHD NIH HHS U10HD21415NICHD NIH HHS U10 HD27851NICHD NIH HHS U10 HD27853NICHD NIH HHS U10 HD27856NICHD NIH HHS U10HD27871NICHD NIH HHS U10 HD27880NICHD NIH HHS U10 HD27881NICHD NIH HHS (U10 HD27904NICHD NIH HHS U10 HD34216NICHD NIH HHS U10 HD36790NICHD NIH HHS U10 HD40461NICHD NIH HHS U10 HD40492NICHD NIH HHS U10 HD40498NICHD NIH HHS U10 HD40521NICHD NIH HHS U10 HD40689NICHD NIH HHS U10 HD53089NICHD NIH HHS U10 HD53109NICHD NIH HHS U10 HD53119NICHD NIH HHS U10 HD53124NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD087229PHS HHS NCRR UL1024160
6 · The paper itself

Abstract

objectiveProphylactic indomethacin reduces severe intraventricular hemorrhage but may increase spontaneous intestinal perforation (SIP) in extremely low birth weight (ELBW) infants. Early feedings improve nutritional outcomes but may increase the risk of SIP. Despite their benefits, use of these therapies varies largely by physician preferences in part because of the concern for SIP.

methodsThis was a cohort study of 15,751 ELBW infants in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network from 1999 to 2010 who survived beyond 12 hours after birth. The risk of SIP was compared between groups of infants with and without exposure to prophylactic indomethacin and early feeding in unadjusted analyses and in analyses adjusted for center and for risks of SIP.

resultsAmong infants exposed to prophylactic indomethacin, the risk of SIP did not differ between the indomethacin/early-feeding group compared with the indomethacin/no-early-feeding group (adjusted relative risk [RR] 0.74, 95% confidence interval [CI] 0.49-1.11). The risk of SIP was lower in the indomethacin/early-feeding group compared with the no indomethacin/no-early-feeding group (adjusted RR 0.58, 95% CI 0.37-0.90, P = .0159). Among infants not exposed to indomethacin, early feeding was associated with a lower risk of SIP compared with the no early feeding group (adjusted RR 0.53, 95% CI 0.36-0.777, P = .0011).

conclusionsThe combined or individual use of prophylactic indomethacin and early feeding was not associated with an increased risk of SIP in ELBW infants.

Indexed as

Infant, Extremely Low Birth WeightCohort StudiesFemaleFollow-Up StudiesHumansIndomethacinInfant, NewbornIntestinal PerforationMaleProspective StudiesRetrospective StudiesIndomethacinindomethacinintestinal perforationnecrotizing enterocolitisneonate

Identifiers

PMID25349317
PMCPMC4533280
OpenAlexW2156011923

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.