Evidence map›Paper›PMID 25349310›Full record

Trial reportPediatrics2014

Prevalence and characteristics of fetal alcohol spectrum disorders.

Philip A May, Amy Baete, Jaymi Russo, Amy J Elliott, Jason Blankenship, Wendy O Kalberg, David Buckley, Marita Brooks, Julie Hasken, Omar Abdul-Rahman and 4 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 286 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
286citing papers in PubMed, 4 pooled it
109.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

286 citing papers in PubMed, 4 syntheses or guidelines pooled it, 560 citations in OpenAlex.

  1. Pooled it
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  3. Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure?Alcoholism, clinical and experimental research · 2018
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226 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Philip A MayDepartment of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center on Alcoholism, Substance Abuse and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico; Department of Pediatrics, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota philip_may@unc.edu.
Amy BaeteSanford Research, Sioux Falls, South Dakota;
Jaymi RussoSanford Research, Sioux Falls, South Dakota;
Amy J ElliottSanford Research, Sioux Falls, South Dakota; Department of Pediatrics, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota.
Jason BlankenshipCenter on Alcoholism, Substance Abuse and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico;
Wendy O KalbergCenter on Alcoholism, Substance Abuse and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico;
David BuckleyCenter on Alcoholism, Substance Abuse and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico;
Marita BrooksCenter on Alcoholism, Substance Abuse and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico;
Julie HaskenDepartment of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;
Omar Abdul-RahmanDepartment of Pediatrics, University of Mississippi, Jackson, Mississippi;
Margaret P AdamDepartment of Pediatrics, University of Washington, Seattle, Washington;
Luther K RobinsonDysmorphology and Clinical Genetics, State University of New York at Buffalo, Buffalo, New York;
Melanie ManningDepartments of Pathology and Pediatrics, Stanford University, Stanford, California; and.
H Eugene HoymeSanford Research, Sioux Falls, South Dakota; Department of Pediatrics, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota.
University of New Mexico · USSanford Research · USUniversity of South Dakota · USStanford University · USUniversity at Buffalo, State University of New York · USUniversity of Mississippi · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · US

Funding

TRIAL OF FAS PREVENTION IN AMERICAN INDIAN COMMUNITIESR01AA011685 · NIAAA · UNIVERSITY OF NEW MEXICO · PI MAY, PHILIP ALAN · 1998 to 2001
$3.1M
NIAAA NIH HHS R01 AA011685NIAAA NIH HHS R01 AA11685NIAAA NIH HHS R01/UO1 AA01115134
6 · The paper itself

Abstract

objectivesTo determine the prevalence and characteristics of fetal alcohol spectrum disorders (FASD) among first grade students (6- to 7-year-olds) in a representative Midwestern US community.

methodsFrom a consented sample of 70.5% of all first graders enrolled in public and private schools, an oversample of small children (≤ 25th percentile on height, weight, and head circumference) and randomly selected control candidates were examined for physical growth, development, dysmorphology, cognition, and behavior. The children's mothers were interviewed for maternal risk.

resultsTotal dysmorphology scores differentiate significantly fetal alcohol syndrome (FAS) and partial FAS (PFAS) from one another and from unexposed controls. Alcohol-related neurodevelopmental disorder (ARND) is not as clearly differentiated from controls. Children who had FASD performed, on average, significantly worse on 7 cognitive and behavioral tests and measures. The most predictive maternal risk variables in this community are late recognition of pregnancy, quantity of alcoholic drinks consumed 3 months before pregnancy, and quantity of drinking reported for the index child's father. From the final multidisciplinary case findings, 3 techniques were used to estimate prevalence. FAS in this community likely ranges from 6 to 9 per 1000 children (midpoint, 7.5), PFAS from 11 to 17 per 1000 children (midpoint, 14), and the total rate of FASD is estimated at 24 to 48 per 1000 children, or 2.4% to 4.8% (midpoint, 3.6%).

conclusionsChildren who have FASD are more prevalent among first graders in this Midwestern city than predicted by previous, popular estimates.

Indexed as

Maternal BehaviorAdultAlcohol DrinkingChildFemaleFetal Alcohol Spectrum DisordersHumansMalePregnancyPrevalenceYoung Adultalcohol use and abusechildren with FASDfetal alcohol spectrum disordersprenatal alcohol useprevalencewomen

Identifiers

PMID25349310
PMCPMC4210790
OpenAlexW2135116344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.