Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2014
Impact of reirradiation of painful osseous metastases on quality of life and function: a secondary analysis of the NCIC CTG SC.20 randomized trial.
Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
In one paragraph
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Evaluation of Quality of Life Outcomes Following Palliative Treatment of Bone Metastases with Magnetic Resonance-guided High Intensity Focused Ultrasound: An International Multicentre Study.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2018Trial
- Minimal clinically important differences in the EORTC QLQ-C30 and brief pain inventory in patients undergoing re-irradiation for painful bone metastases.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Trial
- Reirradiation - still navigating uncharted waters?Clinical and translational radiation oncology · 2024Review
- Multidisciplinary Treatment of Non-Spine Bone Metastases: Results of a Modified Delphi Consensus Process.Clinical and translational radiation oncology · 2022Article
- A surveillance study of patterns of reirradiation practice using external beam radiotherapy in Japan.Journal of radiation research · 2021Article
- Inconsistencies in assessment of pain endpoints in radiotherapy for painful tumors: Analysis of original articles in the Green and Red Journals.Clinical and translational radiation oncology · 2020Article
- Effectiveness and toxicity of conventional radiotherapy treatment for painful spinal metastases: a detailed course of side effects after opposing fields versus a single posterior field technique.Journal of radiation oncology · 2018Article
- Metastatic Osseous Pain Control: Radiation Therapy.Seminars in interventional radiology · 2017Review
- Spine Stereotactic Body Radiotherapy: Indications, Outcomes, and Points of Caution.Global spine journal · 2017Article
- Revisiting classification of pain from bone metastases as mild, moderate, or severe based on correlation with function and quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- The era of stereotactic body radiotherapy for spinal metastases and the multidisciplinary management of complex cases.Neuro-oncology practice · 2016Article
- Index and Nonindex Pain Endpoints in Radiation Therapy for Painful Tumors: A Secondary Analysis of a Prospective Observational Study.Advances in radiation oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 1 institution in 1 country.
Edward ChowEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH. edward.chow@sunnybrook.ca.
Ralph M MeyerEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Bingshu E ChenEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Yvette M van der LindenEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Daniel RoosEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
William F HartsellEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Peter HoskinEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Jackson S Y WuEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Abdenour NabidEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Caroline J A Tissing-TanEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Bing OeiEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Scott BabingtonEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
William F DemasEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Carolyn F WilsonEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Rebecca K S WongEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Michael BrundageEdward Chow, Sunnybrook Odette Cancer Centre, University of Toronto; Rebecca K.S. Wong, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto, Toronto; Ralph M. Meyer, Juravinski Hospital and Cancer Centre and McMaster University, Hamilton; Bingshu E. Chen, Carolyn F. Wilson, and Michael Brundage, Cancer Research Institute, Queen's University, Kingston, Ontario; Jackson S.Y. Wu, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta; Abdenour Nabid, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; Yvette M. van der Linden, Leiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden; Caroline J.A. Tissing-Tan, Institute for Radiation Oncology Arnhem, Arnhem; Bing Oei, Dr Bernard Verbeeten Instituut, Tilburg, the Netherlands; Daniel Roos, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia; William F. Hartsell, Central DuPage Hospital Cancer Center, Warrenville, IL; Peter Hoskin, Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom; Scott Babington, Christchurch Hospital, Christchurch, New Zealand; and William F. Demas, Akron City Hospital, Northeast Ohio Medical University, Akron, OH.
Sunnybrook Health Science Centre · CA
Funding
NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8MRTOG Foreign AccrualU10CA021661 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI CURRAN, WALTER J. · 1985 to 2013
$150.3MStatistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mei-Yin C Polley · 2014 to 2026
$146.4MRTOG Foreign AccrualsU10CA037422 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI BRUNER, DEBORAH WATKINS · 1985 to 2013
$30.4MNCI NIH HHS U10 CA021661NCI NIH HHS U10 CA037422NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868NCI NIH HHS U10 CA21661NCI NIH HHS U10 CA37422
Abstract
purposeWe previously demonstrated that 48% of patients with pain at sites of previously irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating pain also improves patient perception of quality of life (QOL). PATIENTS AND
methodsWe used the database of a randomized trial comparing radiation treatment dose fractionation schedules to evaluate whether response, determined using the International Consensus Endpoint (ICE) and Brief Pain Inventory pain score (BPI-PS), is associated with patient perception of benefit, as measured using the European Organisation for Resesarch and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) and functional interference scale of the BPI (BPI-FI). Evaluable patients completed baseline and 2-month follow-up assessments.
resultsAmong 850 randomly assigned patients, 528 were evaluable for response using the ICE and 605 using the BPI-PS. Using the ICE, 253 patients experienced a response and 275 did not. Responding patients had superior scores on all items of the BPI-FI (ie, general activity, mood, walking ability, normal work, relations with other people, sleep, and enjoyment of life) and improved QOL, as determined by scores on the EORTC QLQ-C30 scales of physical, role, emotional and social functioning, global QOL, fatigue, pain, and appetite. Similar results were obtained using the BPI-PS; observed improvements were typically of lesser magnitude.
conclusionPatients responding to reirradiation of painful bone metastases experience superior QOL scores and less functional interference associated with pain. Patients should be offered re-treatment for painful bone metastases in the hope of reducing pain severity as well as improving QOL and pain interference.
Indexed as
Quality of LifeAdultAgedAged, 80 and overBone NeoplasmsDose Fractionation, RadiationEmotionsFemaleHealth StatusHumansMaleMental HealthMiddle AgedPainPain MeasurementRetreatment
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