ArticleJournal of the American Society of Nephrology : JASN2015
Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model.
Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Risk Factors for Acute Kidney Injury in Critically Ill Neonates: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Glomerular diameter is associated with a reduction in urinary protein by treatment with dapagliflozin in patients with chronic kidney disease.Clinical and experimental nephrology · 2025Article
- Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model.American journal of physiology. Renal physiology · 2025Article
- Early diagnosis of solitary functioning kidney: comparing the prognosis of kidney agenesis and multicystic dysplastic kidney.Pediatric nephrology (Berlin, Germany) · 2024Article
- The Kidney-Gut Axis as a Novel Target for Nutritional Intervention to Counteract Chronic Kidney Disease Progression.Metabolites · 2024Review
- Magnitude and associated factors of acute kidney injury among preterm neonates admitted to public hospitals in Bahir Dar city, Ethiopia 2022: cross-sectional study.BMC pediatrics · 2023Article
- Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions.Current hypertension reports · 2022Review
- Successful single kidney transplantation from pediatric donors less than or equal to 10 kg to adult recipient: a retrospective cohort study.Translational pediatrics · 2021Article
- Nephron-deficient HSRA rats exhibit renal injury with age but have limited renal damage from streptozotocin-induced hyperglycemia.American journal of physiology. Renal physiology · 2021Article
- Loss ofHypertension (Dallas, Tex. : 1979) · 2020Article
- Temporal Expression and Cellular Localization of PAPPA2 in the Developing Kidney of Rat.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Whole genome sequencing and novel candidate genes for CAKUT and altered nephrogenesis in the HSRA rat.Physiological genomics · 2020Article
- A Prediction Nomogram for Acute Kidney Injury in Very-Low-Birth-Weight Infants: A Retrospective Study.Frontiers in pediatrics · 2020Article
- Role of the Primary Cilia on the Macula Densa and Thick Ascending Limbs in Regulation of Sodium Excretion and Hemodynamics.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Single-Nephron Glomerular Filtration Rate in Healthy Adults.The New England journal of medicine · 2017Article
- Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models.Physiological genomics · 2017Review
- Spontaneous one-kidney rats are more susceptible to develop hypertension by DOCA-NaCl and subsequent kidney injury compared with uninephrectomized rats.American journal of physiology. Renal physiology · 2016Article
- Genetic etiology of renal agenesis: fine mapping of Renag1 and identification of Kit as the candidate functional gene.PloS one · 2015Article
- Article
- Transforming Growth Factor-Beta 1 and Endoglin Levels in Congenital Solitary Functioning Kidney.Indian journal of nephrologyArticle
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Some studies have reported up to 40% of patients born with a single kidney develop hypertension, proteinuria, and in some cases renal failure. The increased susceptibility to renal injury may be due, in part, to reduced nephron numbers. Notably, children who undergo nephrectomy or adults who serve as kidney donors exhibit little difference in renal function compared with persons who have two kidneys. However, the difference in risk between being born with a single kidney versus being born with two kidneys and then undergoing nephrectomy are unclear. Animal models used previously to investigate this question are not ideal because they require invasive methods to model congenital solitary kidney. In this study, we describe a new genetic animal model, the heterogeneous stock-derived model of unilateral renal agenesis (HSRA) rat, which demonstrates 50%-75% spontaneous incidence of a single kidney. The HSRA model is characterized by reduced nephron number (more than would be expected by loss of one kidney), early kidney/glomerular hypertrophy, and progressive renal injury, which culminates in reduced renal function. Long-term studies of temporal relationships among BP, renal hemodynamics, and renal function demonstrate that spontaneous single-kidney HSRA rats are more likely than uninephrectomized normal littermates to exhibit renal impairment because of the combination of reduced nephron numbers and prolonged exposure to renal compensatory mechanisms (i.e., hyperfiltration). Future studies with this novel animal model may provide additional insight into the genetic contributions to kidney development and agenesis and the factors influencing susceptibility to renal injury in individuals with congenital solitary kidney.
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