ArticleMolecular psychiatry2015
Genetic background of extreme violent behavior.
Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 215 citations in OpenAlex.
- Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span.BMC psychiatry · 2026Article
- Positive Selection in Aggression-Linked Genes and Their Protein Interaction Networks.Life (Basel, Switzerland) · 2025Article
- Copycat in Suicide: A Systematic Review of the Literature.Journal of clinical medicine · 2024Review
- The Evolution of Forensic Genomics: Regulating Massively Parallel Sequencing.Journal of bioethical inquiry · 2024Article
- Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators.Cancer immunology, immunotherapy : CII · 2024Review
- Article
- Long-Term Soft-Food Rearing in Young Mice Alters Brain Function and Mood-Related Behavior.Nutrients · 2023Article
- Neurotransmitters: promising immune modulators in the tumor microenvironment.Frontiers in immunology · 2023Review
- Theorizing the Role of Dopaminergic Polymorphic Risk Alleles with Intermittent Explosive Disorder (IED), Violent/Aggressive Behavior and Addiction: Justification of Genetic Addiction Risk Severity (GARS) Testing.Journal of personalized medicine · 2022Article
- The Cannabis-Induced Epigenetic Regulation of Genes Associated with Major Depressive Disorder.Genes · 2022Review
- The Microbiota-Gut-Brain Axis: Gut Microbiota Modulates Conspecific Aggression in Diversely Selected Laying Hens.Microorganisms · 2022Article
- Review
- Nanoformulation improves antitumor efficacy of MAOI immune checkpoint blockade therapy without causing aggression-related side effects.Frontiers in pharmacology · 2022Article
- Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Objective Video-Based Assessment of ADHD-Like Canine Behavior Using Machine Learning.Animals : an open access journal from MDPI · 2021Article
- A CommonGenes · 2021Article
- Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.Nature communications · 2021Article
- An Ontological Framework to Facilitate Early Detection of 'Radicalization' (OFEDR)-A Three World Perspective.Journal of imaging · 2021Article
- Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin.Scientific reports · 2021Article
- Psychopathy and Associated Factors Among Newly Admitted Prisoners in Correctional Institution Located in Bench Sheko and West Omo Zone, South West Ethiopia: A Cross-Sectional Study.Psychology research and behavior management · 2021Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 4 countries.
Funding
Abstract
In developed countries, the majority of all violent crime is committed by a small group of antisocial recidivistic offenders, but no genes have been shown to contribute to recidivistic violent offending or severe violent behavior, such as homicide. Our results, from two independent cohorts of Finnish prisoners, revealed that a monoamine oxidase A (MAOA) low-activity genotype (contributing to low dopamine turnover rate) as well as the CDH13 gene (coding for neuronal membrane adhesion protein) are associated with extremely violent behavior (at least 10 committed homicides, attempted homicides or batteries). No substantial signal was observed for either MAOA or CDH13 among non-violent offenders, indicating that findings were specific for violent offending, and not largely attributable to substance abuse or antisocial personality disorder. These results indicate both low monoamine metabolism and neuronal membrane dysfunction as plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5-10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.