Evidence map›Paper›PMID 25349166›Full record

ArticleMolecular psychiatry2015

Deviations in cortex sulcation associated with visual hallucinations in schizophrenia.

A Cachia, A Amad, J Brunelin, M-O Krebs, M Plaze, P Thomas, R Jardri

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  16. The value of doing philosophy in mental health contexts.Medicine, health care, and philosophy · 2020
    Article
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  19. Association between childhood trauma and multimodal early-onset hallucinations.The British journal of psychiatry : the journal of mental science · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

A CachiaINSERM UMR 894, Centre de Psychiatrie & Neurosciences, Paris, France.
A AmadUniversité de Lille, SCA-lab, PSYchiC team, Lille, France.
J BrunelinUniversité Claude Bernard Lyon 1 (UCBL), EA 4615, Centre Hospitalier Le Vinatier, Bron, France.
M-O KrebsINSERM UMR 894, Centre de Psychiatrie & Neurosciences, Paris, France.
M PlazeINSERM UMR 894, Centre de Psychiatrie & Neurosciences, Paris, France.
P ThomasUniversité de Lille, SCA-lab, PSYchiC team, Lille, France.
R JardriUniversité de Lille, SCA-lab, PSYchiC team, Lille, France.ORCID http://orcid.org/0000-0003-4596-1502
Délégation Paris 5 · FRUniversité de Lille · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hallucinations, and auditory hallucinations (AH) in particular, constitute the most typical and disabling schizophrenia symptoms. Although visual hallucinations (VH) have been largely neglected in psychiatric disorders, a recent review reported a 27% mean prevalence of VH in schizophrenia patients. The pathophysiology underlying VH in schizophrenia remains elusive. Several schizophrenia studies reported a significant effect of age on VH; therefore, we tested the hypothesis that the neurodevelopmental model of schizophrenia may explain VH occurrence. We analyzed cortex sulcation, a marker of brain development, in healthy controls (HCs) and two subgroups of carefully selected schizophrenia patients suffering from hallucinations: patients with only AH (that is, patients who never reported VH) and patients with audio-visual hallucinations (A+VH). Different cortical sulcation and left-right sulcal asymmetry were found between A+VH and AH patients, with decreased sulcation in both A+VH and AH patients in comparison with the HCs. Although a specific association between VH and neurodegenerative mechanisms, for example, in Body-Lewy Dementia or Parkinson's Disease, has previously been reported in the literature, the current study provides the first neuroimaging evidence of an association between VH and neurodevelopmental mechanisms.

Indexed as

AdultBrainCase-Control StudiesDiffusion Magnetic Resonance ImagingFemaleHallucinationsHumansMaleSchizophrenia

Identifiers

PMID25349166
OpenAlexW2088942555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.