Evidence map›Paper›PMID 25349164›Full record

ArticleMolecular psychiatry2015

Molecular psychiatry of zebrafish.

A M Stewart, J F P Ullmann, W H J Norton, M O Parker, C H Brennan, R Gerlai, A V Kalueff

Abstract read
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. International journal of molecular sciences · 2026
    Article
  3. Behavioral, Biochemical, andPharmaceuticals (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Alterations ofmicroPublication biology · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Delivering Traumatic Brain Injury to Larval Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A M Stewart1] ZENEREI Institute, Slidell, LA, USA [2] International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
J F P Ullmann1] International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA [2] Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia.
W H J Norton1] International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA [2] Department of Biology, College of Medicine, Biological Sciences and Psychiatry, University of Leicester, Leicester, UK.
M O ParkerSchool of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
C H BrennanSchool of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
R GerlaiDepartment of Psychology, University of Toronto at Mississauga, Mississauga, Ontario, Canada.
A V Kalueff1] ZENEREI Institute, Slidell, LA, USA [2] International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA [3] Research Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China.

Funding

Alcohol and zebra fish: Behavioral screens for mutantsR01AA015325 · NIAAA · UNIVERSITY OF TORONTO · PI GERLAI, ROBERT T. · 2007 to 2011
$1.2M
Developing adult zebrafish-based models to study hallucinogenic drug actionR03DA030900 · NIDA · TULANE UNIVERSITY OF LOUISIANA · PI KALUEFF, ALLAN V · 2010 to 2012
$87k
A population-bases atlas of the zebrafish brain for quantitative phenotypic compaR03NS077295 · NINDS · UNIVERSITY OF QUEENSLAND · PI JANKE, ANDREW LINDSAY, KURNIAWAN, NYOMAN DANA · 2011 to 2012
$78k
Medical Research CouncilNational Centre for the Replacement, Refinement and Reduction of Animals in Research G1000053/1NIAAA NIH HHS AA015325-01A2NIAAA NIH HHS R01 AA015325NIDA NIH HHS DA030900-02NIDA NIH HHS R03 DA030900NINDS NIH HHS NS077295-01NINDS NIH HHS R03 NS077295
6 · The paper itself

Abstract

Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.

Indexed as

Disease Models, AnimalTranslational Research, BiomedicalAnimalsCentral Nervous System DiseasesMental DisordersZebrafish

Identifiers

PMID25349164
PMCPMC4318706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.