Evidence map›Paper›PMID 25349147›Full record

ArticleThe Journal of comparative neurology2015

Vulnerability of the medial frontal corticospinal projection accompanies combined lateral frontal and parietal cortex injury in rhesus monkey.

R J Morecraft, J Ge, K S Stilwell-Morecraft, D W McNeal, S M Hynes, M A Pizzimenti, D L Rotella, W G Darling

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

R J MorecraftDivision of Basic Biomedical Sciences, Laboratory of Neurological Sciences, The University of South Dakota, Sanford School of Medicine, Vermillion, South Dakota, 57069.
J Ge
K S Stilwell-Morecraft
D W McNeal
S M Hynes
M A Pizzimenti
D L Rotella
W G Darling
University of Iowa · USUniversity of South Dakota · US

Funding

Mechanisms of Motor Recovery after Subtotal Brain InjuryR01NS046367 · NINDS · UNIVERSITY OF SOUTH DAKOTA · PI MORECRAFT, ROBERT J · 2004 to 2013
$3.2M
Mechanisms of Motor Recovery after subtotal Brain InjuryR56NS046367 · NINDS · UNIVERSITY OF SOUTH DAKOTA · PI MORECRAFT, ROBERT J · 2009 to 2009
$431k
NINDS NIH HHS NS 046367NINDS NIH HHS R01 NS046367NINDS NIH HHS R56 NS046367
6 · The paper itself

Abstract

Concurrent damage to the lateral frontal and parietal cortex is common following middle cerebral artery infarction, leading to upper extremity paresis, paresthesia, and sensory loss. Motor recovery is often poor, and the mechanisms that support or impede this process are unclear. Since the medial wall of the cerebral hemisphere is commonly spared following stroke, we investigated the spontaneous long-term (6 and 12 month) effects of lateral frontoparietal injury (F2P2 lesion) on the terminal distribution of the corticospinal projection (CSP) from intact, ipsilesional supplementary motor cortex (M2) at spinal levels C5 to T1. Isolated injury to the frontoparietal arm/hand region resulted in a significant loss of contralateral corticospinal boutons from M2 compared with controls. Specifically, reductions occurred in the medial and lateral parts of lamina VII and the dorsal quadrants of lamina IX. There were no statistical differences in the ipsilateral CSP. Contrary to isolated lateral frontal motor injury (F2 lesion), which results in substantial increases in contralateral M2 labeling in laminae VII and IX (McNeal et al. [2010] J. Comp. Neurol. 518:586-621), the added effect of adjacent parietal cortex injury to the frontal motor lesion (F2P2 lesion) not only impedes a favorable compensatory neuroplastic response but results in a substantial loss of M2 CSP terminals. This dramatic reversal of the CSP response suggests a critical trophic role for cortical somatosensory influence on spared ipsilesional frontal corticospinal projections, and that restoration of a favorable compensatory response will require therapeutic intervention.

Indexed as

AnimalsFemaleFrontal LobeFunctional LateralityHandImmunohistochemistryMacaca mulattaMaleMotor ActivityNeuroanatomical Tract-Tracing TechniquesParietal LobePhotomicrographyPresynaptic TerminalsPyramidal TractsRecovery of FunctionTime Factorscorticofugalfrontal lobehand movementsmotor recoveryneurosurgical resectionparietal lobeplasticitypyramidal tractspinal cord

Identifiers

PMID25349147
PMCPMC4304964
OpenAlexW2172144684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.